Abstract:
:c-Myc is a transcriptional regulator involved in carcinogenesis through its role in growth control and cell cycle progression. Here we attempt to relate its role in stimulating the G1-S transition to the ability to affect functioning of key cell cycle regulators, and we focus on how its property of modulating transcription of a wide range of target genes could explain its capacity to affect multiple pathways leading to proliferation, apoptosis, growth, and transformation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Nasi S,Ciarapica R,Jucker R,Rosati J,Soucek Ldoi
10.1016/s0014-5793(01)02118-4keywords:
subject
Has Abstractpub_date
2001-02-16 00:00:00pages
153-62issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(01)02118-4journal_volume
490pub_type
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