Making decisions through Myc.

Abstract:

:c-Myc is a transcriptional regulator involved in carcinogenesis through its role in growth control and cell cycle progression. Here we attempt to relate its role in stimulating the G1-S transition to the ability to affect functioning of key cell cycle regulators, and we focus on how its property of modulating transcription of a wide range of target genes could explain its capacity to affect multiple pathways leading to proliferation, apoptosis, growth, and transformation.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Nasi S,Ciarapica R,Jucker R,Rosati J,Soucek L

doi

10.1016/s0014-5793(01)02118-4

keywords:

subject

Has Abstract

pub_date

2001-02-16 00:00:00

pages

153-62

issue

3

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(01)02118-4

journal_volume

490

pub_type

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