Abstract:
:The diterpene forskolin stimulated rat cardiac adenylate cyclase activity at least 20-fold and potentiated the effect of NaF. The stimulatory effect of forskolin was reduced in the presence of Gpp(NH)p. Ethanol markedly reduced the stimulation of adenylate cyclase by forskolin while potentiating NaF and Gpp(NH)p stimulation. The inhibitory effect of ethanol on forskolin stimulation appeared to be of a mixed type with both a competitive and a non-competitive component. Three other short-chain linear alcohols (methanol, propanol, butanol) also inhibited forskolin-stimulation, this effect being proportional to the number of carbon atoms.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Robberecht P,Waelbroeck M,Chatelain P,Camus JC,Christophe Jdoi
10.1016/0014-5793(83)80904-1subject
Has Abstractpub_date
1983-04-05 00:00:00pages
205-8issue
1eissn
0014-5793issn
1873-3468journal_volume
154pub_type
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