Abstract:
:Using an in vitro co-culture approach comprising cultured murine superior cervical ganglia and MC3T3-E1 osteoblast-like cells, we found that the addition of scorpion venom (SV) elicited neurite activation via intracellular Ca2+ mobilization and, after a lag period, osteoblastic Ca2+ mobilization. SV did not have any direct effect on the osteoblastic cells in the absence of neurites. The addition of an alpha1-adrenergic receptor (AR) antagonist, prazosin, dose-dependently prevented the osteoblastic activation that resulted as a consequence of neural activation by SV. These results demonstrate that osteoblastic activation occurred as a direct response to neuronal activation, which activation was mediated by alpha1-ARs in the osteoblastic cells.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Obata K,Furuno T,Nakanishi M,Togari Adoi
10.1016/j.febslet.2007.11.065subject
Has Abstractpub_date
2007-12-22 00:00:00pages
5917-22issue
30eissn
0014-5793issn
1873-3468pii
S0014-5793(07)01219-7journal_volume
581pub_type
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