Abstract:
:C2cd4c, encoded by a gene belonging to the C2cd4 family, contains a C2 domain conserved across species and is localized to the cytoplasm. To examine the role of C2cd4c in the pancreas, we studied its localization and generated C2cd4c knockout (KO) mice. C2cd4c was expressed in pancreatic endocrine progenitors at early embryonic stages. When endocrine cells arise from their precursors, C2cd4c is gradually confined to the insulin- and pancreatic polypeptide-expressing cells of the endocrine. In the adult pancreas, C2cd4c is restricted to the beta cells. C2cd4c KO mice showed normal embryonic pancreatic development and adult pancreatic function. Thus, our results suggest that C2cd4c is dispensable for pancreatic development.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Omori H,Ogaki S,Sakano D,Sato M,Umeda K,Takeda N,Nakagata N,Kume Sdoi
10.1002/1873-3468.12271subject
Has Abstractpub_date
2016-08-01 00:00:00pages
2584-93issue
16eissn
0014-5793issn
1873-3468journal_volume
590pub_type
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