Abstract:
:Co-infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) is common and is associated with a more severe liver disease and increased frequency in the development of hepatocellular carcinoma (HCC). Here, we demonstrated that HBV X protein (HBx) and HCV core protein additively repress the universal cyclin-dependent kinase inhibitor p21 gene at the transcription level. The transforming growth factor-beta responsive element and Sp1 site of the p21 promoter were responsible for the effect of HCV core and HBx, respectively. Furthermore, cell growth was additively stimulated by them, suggesting that additive repression of the p21 might be important to understand the cooperative development of HCC by HBV and HCV.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Han HJ,Jung EY,Lee WJ,Jang KLdoi
10.1016/s0014-5793(02)02694-7keywords:
subject
Has Abstractpub_date
2002-05-08 00:00:00pages
169-72issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579302026947journal_volume
518pub_type
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