Abstract:
:Regulation of Na(+)-dependent glutamate transport was studied in isolated luminal and abluminal plasma membranes derived from the bovine blood-brain barrier. Abluminal membranes have Na(+)-dependent glutamate transporters while luminal membranes have facilitative transporters. This organization allows glutamate to be actively removed from brain. gamma-Glutamyl transpeptidase, the first enzyme of the gamma-glutamyl cycle (GGC), is on the luminal membrane. Pyroglutamate (oxoproline), an intracellular product of GGC, stimulated Na(+)-dependent transport of glutamate by 46%, whereas facilitative glutamate uptake in luminal membranes was inhibited. This relationship between GGC and glutamate transporters may be part of a regulatory mechanism that accelerates glutamate removal from brain.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hawkins RA,Simpson IA,Mokashi A,Viña JRdoi
10.1016/j.febslet.2006.06.097subject
Has Abstractpub_date
2006-08-07 00:00:00pages
4382-6issue
18eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00829-5journal_volume
580pub_type
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