Abstract:
:In this study, we demonstrated that tissue inhibitor of metalloproteinases (TIMP) produced by human bone marrow stromal cell line KM-102 had erythroid-potentiating activity (EPA) which stimulates the proliferation of erythroid progenitor cells. We, then, propose a scheme for the bifunctional role of TIMP/EPA in hematopoietic microenvironment, that is, the maintenance of the integrity of bone marrow matrix and the proliferation of erythroid progenitor cells proceeding on the matrix.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hayakawa T,Yamashita K,Kishi J,Harigaya Kdoi
10.1016/0014-5793(90)80989-vsubject
Has Abstractpub_date
1990-07-30 00:00:00pages
125-8issue
1eissn
0014-5793issn
1873-3468journal_volume
268pub_type
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