Abstract:
:Human monocyte-macrophages were incubated for 24 h in Ham's F-10 medium with human low-density lipoprotein (LDL) in the presence or absence of beta-carotene, canthaxanthin or zeaxanthin, at final concentrations of 2.5, 12.5 and 25 mg/l. LDL oxidation, measured by agarose gel electrophoresis, the thiobarbituric acid assay and gas chromatography, was inhibited by each of the carotenoids in a concentration-dependent manner. Canthaxanthin was more effective when incorporated into LDL before addition to the cultures whereas beta-carotene and zeaxanthin were more effective when added simultaneously with LDL. The results suggest that dietary carotenoids might help slow atherosclerosis progression.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Carpenter KL,van der Veen C,Hird R,Dennis IF,Ding T,Mitchinson MJdoi
10.1016/s0014-5793(96)01488-3subject
Has Abstractpub_date
1997-01-20 00:00:00pages
262-6issue
2-3eissn
0014-5793issn
1873-3468pii
S0014-5793(96)01488-3journal_volume
401pub_type
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