Abstract:
:We previously found a brain-specific glycoprotein in the rat brain. It postnatally increases and is rich in the mature brain. We cloned cDNA of this protein. It is composed of a signal peptide, a V-type immunoglobulin domain, two C1-type immunoglobulin domains, a transmembrane segment and a cytoplasmic region containing two tyrosine-based activation motifs (TAM) that are variants of the antigen receptor signaling motifs. The overall structure is similar to those of immune antigen receptors. This molecule, BIT (brain immunoglobulin-like molecule with TAMs), is a major endogenous substrates of brain tyrosine kinases in vitro. Cerebral cortical neurons could extend their neurites on BIT-coated substrate and anti-BIT monoclonal antibody specifically inhibited the effect. These findings and our recent study concerning BIT signal transduction mechanism suggest that BIT, an immune antigen receptor-like molecule of the brain, functions as a membrane signaling molecule that may participate in cell-cell interaction.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sano S,Ohnishi H,Omori A,Hasegawa J,Kubota Mdoi
10.1016/s0014-5793(97)00724-2subject
Has Abstractpub_date
1997-07-14 00:00:00pages
327-34issue
2-3eissn
0014-5793issn
1873-3468pii
S0014579397007242journal_volume
411pub_type
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