Abstract:
:Sperm beta-acrosin activity is inhibited by suramin, a polysulfonated naphthylurea compound with therapeutic potential as a combined antifertility agent and microbicide. A kinetic analysis of enzyme inhibition suggests that three and four molecules of suramin bind to one molecule of ram and boar beta-acrosins respectively. Surface charge distribution models of boar beta-acrosin based on its crystal structure indicate several positively charged exosites that represent potential 'docking' regions for suramin. It is hypothesised that the spatial arrangement and distance between these exosites determines the capacity of beta-acrosin to bind suramin.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Hermans JM,Haines DS,James PS,Jones Rdoi
10.1016/s0014-5793(03)00488-5keywords:
subject
Has Abstractpub_date
2003-06-05 00:00:00pages
119-22issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579303004885journal_volume
544pub_type
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