Abstract:
:Antipsychotic drugs of known antidiarrhoeal and anticalmodulin activity inhibited the cholera-toxin-catalysed ADP-ribosylation of proteins of Mr 37,000, 40,000 and 45,000 (thought to be regulatory components of the adenylate cyclase complex) that was previously shown to occur in plasma membranes from rabbit intestinal epithelial cells [(1989) Biochim. Biophys. Acta 1014, 289-297]. There was no obvious correlation between the different activities of the drugs. The drugs also inhibited adenylate cyclase activity, but in this case the inhibition correlated well with the known IC50 values of the drugs for anticalmodulin activity and with their antidiarrhoeal activities.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Longbottom D,van Heyningen Sdoi
10.1016/0014-5793(90)80444-nsubject
Has Abstractpub_date
1990-10-15 00:00:00pages
41-4issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(90)80444-Njournal_volume
272pub_type
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