Abstract:
:Though phospholipase C PLCgamma2 is known to play an important role in platelet activation by collagen and fibrinogen, its importance in GPIb-mediated platelet activation is less well understood. To better understand the role of PLCgamma2 in GPIb-mediated adhesion and thrombus formation, we examined the ability of wild-type and PLCgamma2- deficient murine platelets to spread on immobilized von Willebrand factor (VWF) under static conditions, and to attach to and form thrombi on VWF under conditions of arterial shear. While absence of PLCgamma2 had only a minimal effect on platelet adhesion to immobilized VWF, its absence impaired spreading and profoundly affected thrombus growth and stability on VWF.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rathore V,Wang D,Newman DK,Newman PJdoi
10.1016/j.febslet.2004.07.048keywords:
subject
Has Abstractpub_date
2004-08-27 00:00:00pages
26-30issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579304009251journal_volume
573pub_type
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