Abstract:
:Contrary to previously published data, we have found that in mammalian skeletal muscles, phosphoglycerate mutase (PGM) is organized in a regular, striated fashion within the sarcomere. In the absence of the enzyme effectors, PGM localizes mainly at the M-line, but under conditions typical for contracting muscle, the enzyme accumulates within the I-band of the sarcomere. Searching for muscle PGM binding partners, we have found that PGM interacts with several enzymes of triose phosphate metabolism. It might suggest that PGM is a central structural element of the muscle glycolytic complex located within the isotropic region of the sarcomere.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Kowalski W,Gizak A,Rakus Ddoi
10.1016/j.febslet.2009.05.004subject
Has Abstractpub_date
2009-06-18 00:00:00pages
1841-5issue
12eissn
0014-5793issn
1873-3468pii
S0014-5793(09)00355-Xjournal_volume
583pub_type
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