Abstract:
:Biochemical, immunohistochemical and molecular biological methods were used to detect fetal myosin heavy chain (MyHC) in the human masseter of elderly and young subjects. Samples from the elderly subjects contained larger amounts of fetal MyHC than those of young adults. Only a very small amount of embryonic MyHC could be detected in both age groups. Embryonic and fetal MyHCs were never detected in the control adult orofacial, limb and trunk muscles. Polymerase chain reaction (PCR) analysis revealed the presence of fetal mRNA sequences in elderly and young masseter muscles. We conclude that fetal MyHC is present in the human masseter throughout the life span and that there is an increase in the relative amount of this protein with age.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Monemi M,Eriksson PO,Dubail I,Butler-Browne GS,Thornell LEdoi
10.1016/0014-5793(96)00402-4subject
Has Abstractpub_date
1996-05-13 00:00:00pages
87-90issue
1eissn
0014-5793issn
1873-3468pii
0014579396004024journal_volume
386pub_type
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