Abstract:
:The effects of nine drugs on the CD spectra of a synthetic calcium binding analog of site III of rabbit skeletal troponin C, can generally be divided into 3 groups: (1) that consisting of haloperidol, benperidol, molindone and promethazine, had no effect on the CD spectrum or calcium sensitivity of the apopeptide; (2) that composed of structurally rigid thioxanthenes, induced CD-detectable structural change in the apopeptide but prevented Ca2+-induced structural change; (3) that consisting of chlorpromazine, trifluoperazine and fluphenazine, induced structural change in the peptide but had no effect on the Ca2+-induced structural change.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Reid RE,Gariépy J,Hodges RSdoi
10.1016/0014-5793(83)80875-8subject
Has Abstractpub_date
1983-04-05 00:00:00pages
60-4issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(83)80875-8journal_volume
154pub_type
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