Abstract:
:F-box proteins play pivotal roles in multiple cellular processes; however, little is known about their functions in glioma progression. In this study, we found that expression of the F-box and leucine-rich repeat protein 18 (FBXL18) is significantly upregulated in glioma tissues. Depletion of FBXL18 in glioma cells suppresses proliferation and anchorage-independent cell growth, and promotes apoptosis. We also demonstrate that depletion of FBXL18 significantly inhibits Akt activity and the phosphorylation of FOXO3a, which leads to upregulation of BCL2L11. Further mechanistic analyses indicate that FBXL18 promotes the K63-linked ubiquitination of Akt, which is required for its activation. Taken together, our results suggest that FBXL18 plays an oncogenic role through promoting K63-linked ubiquitination of Akt in glioma.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Zhang J,Yang Z,Ou J,Xia X,Zhi F,Cui Jdoi
10.1002/1873-3468.12521subject
Has Abstractpub_date
2017-01-01 00:00:00pages
145-154issue
1eissn
0014-5793issn
1873-3468journal_volume
591pub_type
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