Abstract:
:Xanthine oxidase was decreased 2- to 10-fold in all examined rat hepatomas irrespective of the malignancy; growth rate and degrees of histological differentiation of the neoplasms. The affinity to substrate (KM=6-8 muM) and the pH optimum (8.0) of the liver and hepatoma enzymes were the same. The reprogramming of gene expression, as manifested in the decreased activity of this key purine metabolizing enzyme, appears to be specific to neoplastic transformation. Since glutamine PRPP amidotransferase activity was increased but the opposing enzyme, xanthine oxidase, was decreased in all the hepatomas, the reprogramming of gene expression results in an imbalance that favors synthesis against catabolism. This enzymatic imbalance should confer selective advantages to the cancer cells.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Prajda N,Weber Gdoi
10.1016/0014-5793(75)80385-1subject
Has Abstractpub_date
1975-11-15 00:00:00pages
245-9issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(75)80385-1journal_volume
59pub_type
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