Abstract:
:The cytosolic NADP(+)-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase is ubiquitously expressed in all mouse tissues and cell lines examined. Northern analyses of the RNA indicated that there is an extensive variation in the levels of mRNA in different tissues. However, the gene is refractory to induction by serum, phorbol esters or growth factors in cultured fibroblasts. The mRNA of the NADP(+)-dependent trifunctional enzyme is stabilized post-transcriptionally by insulin-like growth factor-1.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Peri KG,MacKenzie REdoi
10.1016/0014-5793(91)81354-bsubject
Has Abstractpub_date
1991-12-02 00:00:00pages
113-5issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(91)81354-Bjournal_volume
294pub_type
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