Abstract:
:tRNAs play a central role in protein translation, acting as the carrier of amino acids. By cloning microRNAs, we unexpectedly obtained some tRNA fragments generated by tRNA cleavage in the anticodon loop. These tRNA fragments are present in many cell lines and different mouse tissues. In addition, various stress conditions can induce this tRNA cleavage event in mammalian cells. More importantly, angiogenin (ANG), a member of RNase A superfamily, appears to be the nuclease which cleaves tRNAs into tRNA halves in vitro and in vivo. These results imply that angiogenin plays an important physiological role in cell stress response, except for the known function of inducing angiogenesis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Fu H,Feng J,Liu Q,Sun F,Tie Y,Zhu J,Xing R,Sun Z,Zheng Xdoi
10.1016/j.febslet.2008.12.043subject
Has Abstractpub_date
2009-01-22 00:00:00pages
437-42issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(08)01035-1journal_volume
583pub_type
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