Abstract:
:Neuritic plaques are the key pathological feature of Alzheimer's disease, and amyloid beta (Abeta) peptides are major component of these plaques. In this study, we demonstrated the influence of aluminum (Al) on the Abeta peptide degradation by cathepsin D. Al did not directly affect the cathepsin D activity using small synthetic substrate. However, when Abeta peptides were used as substrate, the apparent inhibitory effect of Al on cathepsin D activity was observed. This inhibitory effect disappeared by treatment of desferrioxamine. These results indicate that Al has the potential to interact and disrupt Abeta peptide catabolism via the inhibition of proteolytic degradation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Sakamoto T,Saito H,Ishii K,Takahashi H,Tanabe S,Ogasawara Ydoi
10.1016/j.febslet.2006.10.075subject
Has Abstractpub_date
2006-12-11 00:00:00pages
6543-9issue
28-29eissn
0014-5793issn
1873-3468pii
S0014-5793(06)01308-1journal_volume
580pub_type
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