Abstract:
:S100, a subfamily of the EF-hand type calcium sensing proteins, is implicated in many cellular functions including muscle contractility. Two isoforms, S100A1 and S100B, at 2-10 microM significantly inhibit active tension, stiffness and ATPase of skinned single rabbit psoas muscle fibers at sub-maximal (pCa approximately 6.1-5.6), but not at maximal levels of activation (pCa 4.0). S100A1 is a more potent inhibitor than S100B. Hill analysis of the ATPase-pCa and tension-pCa curves indicates that these proteins reduce calcium sensitivity and enhance the cooperativity toward calcium. We propose S100A1, and perhaps S100B, are viable candidates as physiological modulators of muscle contraction.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Adhikari BB,Wang Kdoi
10.1016/s0014-5793(01)02444-9keywords:
subject
Has Abstractpub_date
2001-05-25 00:00:00pages
95-8issue
2-3eissn
0014-5793issn
1873-3468pii
S0014-5793(01)02444-9journal_volume
497pub_type
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