Abstract:
:The widely studied macrophage scavenger receptor system is known to bind both acetylated low density lipoprotein and oxidized low density lipoprotein. Although only the latter ligand has been shown to occur in vivo, acetylated low density lipoprotein is often used to evaluate the contribution of scavenger receptors to different (patho)physiologic processes, assuming that all existing subtypes of scavenger receptors recognise both lipoproteins. In the present work, we identify human platelets as the first natural cell type to bind oxidized low density lipoprotein without showing specificity for acetylated low density lipoprotein. Consequently, platelets possess exclusive receptor(s) for oxidized low density lipoprotein distinct from the 'classical' scavenger receptor AI/AII. From the data presented in this work, we conclude that the class B scavenger receptor CD36 (GPIV) is responsible for this exclusive oxidized low density lipoprotein binding.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Volf I,Moeslinger T,Cooper J,Schmid W,Koller Edoi
10.1016/s0014-5793(99)00437-8keywords:
subject
Has Abstractpub_date
1999-04-23 00:00:00pages
141-5issue
2-3eissn
0014-5793issn
1873-3468pii
S0014-5793(99)00437-8journal_volume
449pub_type
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