Abstract:
:Protein gene product 9.5 (PGP 9.5), which in the normal nervous system is restricted to certain neurons, has been detected in two glioma cell lines, rat C6 and human GL15, by immunoblotting and immunocytochemistry. Its expression in these cells depends on the cellular growth state, being maximal between the first and second post-plating day. Only a faint PGP 9.5 immunoreactivity can be observed in glioma cells after the eleventh post-plating day, i.e. about one week after confluency has been reached. The present results suggest that PGP 9.5 in cultured glial cells is maximally expressed during the growth phase and that the protein could play a role during brain development in glial cells, in reactive gliosis, or in tumorigenesis of the glial lineage.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Giambanco I,Bianchi R,Ceccarelli P,Pula G,Sorci G,Antonioli S,Bocchini V,Donato Rdoi
10.1016/0014-5793(91)81242-zsubject
Has Abstractpub_date
1991-09-23 00:00:00pages
131-4issue
1-2eissn
0014-5793issn
1873-3468pii
0014-5793(91)81242-Zjournal_volume
290pub_type
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