Abstract:
:Several lines of evidence indicate that selenoproteins mainly act as cellular antioxidants. Here, we test this idea comparing the sensitivity to oxidative stress (paraquat and hydrogen peroxide) between wild type and heterozygous flies for the selenophosphate synthetase selD(ptuf) mutation. Whereas under normal laboratory conditions no difference in life span is observed, a significant decrease is seen in heterozygous flies treated with oxidant agents. In contrast, overexpression of the selD gene in motoneurons did not extend longevity. Our results strongly suggest that selD haploinsufficiency makes heterozygous flies more sensitive to oxidative stress and add further evidence to the role of selenoproteins as cellular antioxidants.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Morey M,Serras F,Corominas Mdoi
10.1016/s0014-5793(02)03790-0keywords:
subject
Has Abstractpub_date
2003-01-16 00:00:00pages
111-4issue
1-3eissn
0014-5793issn
1873-3468pii
S0014579302037900journal_volume
534pub_type
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