Cyclosporin A inhibits H2O2-induced apoptosis of human fibroblasts.

abstract：:Because A2 adenosine receptor activation stimulates adenylate cyclase and cyclic AMP induces 5'-nucleotidase expression in rat mesangial cells, we examined the effect of adenosine and its analogs on 5'-nucleotidase activity in these cells. A2 adenosine receptors were characterized using [3H]5'-N-ethylcarboxamidoadenos...

journal_title：FEBS letters

authors： Stefanovic V,Vlahovic P,Savic V,Ardaillou N,Ardaillou R

更新日期：1993-09-27 00:00:00

abstract：:Annexin V is an alpha-helical protein which shows anticoagulatory and antiinflammatory activity. It is supposed to be involved in membrane fusion and exocytosis. In this study acid-induced equilibrium unfolding of the human annexin V is investigated by fluorescence and circular dichroism spectroscopy. The spectroscopi...

journal_title：FEBS letters

authors： Beermann ofm cap BB,Hinz HJ,Hofmann A,Huber R

更新日期：1998-02-20 00:00:00

abstract：:Antibodies were made to a thirteen amino acid synthetic peptide corresponding to the C-terminal portion of the glutamate (glu) receptor, GluR-A. The immunoprecipitation of kainic acid (KA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) binding sites by the anti-peptide antibodies was studied using...

journal_title：FEBS letters

authors： Wenthold RJ,Hunter C,Wada K,Dechesne CJ

更新日期：1990-12-10 00:00:00

abstract：:The mitochondrial outer membrane contains a protein complex with at least eight subunits responsible for recognition and translocation of preproteins synthesized in the cytosol. Two subunits, the receptors Tom20 and Tom70, contain tetratrico peptide repeats that are thought to be involved in protein-protein interactio...

journal_title：FEBS letters

authors： Bömer U,Pfanner N,Dietmeier K

更新日期：1996-03-11 00:00:00

abstract：:Leishmania major promastigotes are parasites endowed with a plasma membrane electrogenic H+ pump and anionic channels. These systems have been thought to contribute to pH homeostasis of parasites and environmental adaptation by mediating extrusion of protons which are either generated metabolically or result from exog...

journal_title：FEBS letters

authors： Vieira L,Cabantchik ZI

更新日期：1995-03-13 00:00:00

abstract：:Conformational changes in the extradiscal regions of rhodopsin induced by illumination were investigated by modifying the visual pigment by mild treatment with cyanogen bromide prior to and after light exposure. Light induced an increased yield of cleavage of the Met bond 253-254 and a new cleavage at the Met bond 155...

journal_title：FEBS letters

authors： Pellicone C,Nullans G,Virmaux N

更新日期：1985-02-11 00:00:00

abstract：:Barth syndrome (BTHS) is a rare X-linked genetic disorder caused by mutations in the gene encoding the transacylase tafazzin and characterized by loss of cardiolipin and severe cardiomyopathy. Mitochondrial oxidants have been implicated in the cardiomyopathy in BTHS. Eleven mitochondrial sites produce superoxide/hydro...

journal_title：FEBS letters

authors： Goncalves RLS,Schlame M,Bartelt A,Brand MD,Hotamışlıgil GS

更新日期：2020-10-28 00:00:00

abstract：:Insertion and deletion analyses of a protein have been less common than point mutation analyses, partly due to the lack in effective methods. This is the case with the green fluorescent protein (GFP), which is so widely applied in molecular biology and other fields. In this paper we first introduce a systematic approa...

journal_title：FEBS letters

authors： Kitamura K,Yoshida C,Nishigaki K

更新日期：2003-12-18 00:00:00

abstract：:Modelling the amino acid sequence of NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase into the three-dimensional structure of 3 alpha/20 beta-hydroxysteroid dehydrogenase shows that these two enzymes, as well as the NADP(+)-linked prostaglandin dehydrogenase (identical to carbonyl reductase) have similar conformati...

journal_title：FEBS letters

authors： Krook M,Ghosh D,Duax W,Jörnvall H

更新日期：1993-05-10 00:00:00

abstract：:Post-transcriptional regulation of gene expression by RNA-binding proteins and by small non-coding RNAs plays an important role in cell biology. Our previous results show that in murine skeletal myoblasts, the expression of Pinch-2, a focal adhesion remodeling factor that regulates cell motility, is repressed by an RN...

journal_title：FEBS letters

authors： Boudoukha S,Rivera Vargas T,Dang I,Kropp J,Cuvellier S,Gautreau A,Polesskaya A

更新日期：2014-05-02 00:00:00

abstract：:Low density lipoproteins are highly sensitive to oxidation by copper salts, and such peroxidation is accompanied by macrophage scavenger receptor recognition. This study shows that fresh human atherosclerotic material (aneurysms and endarterectomies) can contain detectable amounts of redox active iron and copper that ...

journal_title：FEBS letters

authors： Swain J,Gutteridge JM

更新日期：1995-07-24 00:00:00

abstract：:We have cloned a novel nuclear gene for a ribosomal protein of rice and Arabidopsis that is like the bacterial ribosomal protein S9. To determine the subcellular localization of the gene product, we fused the N-terminal region and green fluorescent protein and expressed it transiently in rice seedlings. Localized fluo...

journal_title：FEBS letters

authors： Arimura S,Takusagawa S,Hatano S,Nakazono M,Hirai A,Tsutsumi N

更新日期：1999-05-07 00:00:00

abstract：:Recent studies have shown that p21-activated kinase 1 (Pak1) phosphorylates estrogen receptor-alpha (ER alpha) at Ser 305 and also promotes its transactivation function. Here, we sought to investigate whether substitution of serine 305 in ER with glutamic acid (ER alpha-S305E), which mimics the phosphorylation state, ...

journal_title：FEBS letters

authors： Balasenthil S,Barnes CJ,Rayala SK,Kumar R

更新日期：2004-06-04 00:00:00

abstract：:The voltage-dependent calcium channel (VDCC) in skeletal muscle probably plays a key role in transducing membrane charge movement to the calcium release channel. We report here that the expression of VDCC alpha 1 and alpha 2 mRNAs is developmentally regulated in differentiating C2C12 myogenic cells. The alpha 1 mRNA i...

journal_title：FEBS letters

authors： Varadi G,Orlowski J,Schwartz A

更新日期：1989-07-03 00:00:00

abstract：:Blebs of the sarcoplasmic reticulum (SR) membrane of heart muscle cells were generated after saponin perforation of the plasma membrane followed by complete hypercontraction of the cell. Although characteristic proteins of the plasma membrane, namely the beta1-adrenoreceptor and Galphai, were stained by monoclonal ant...

journal_title：FEBS letters

authors： Böhle T,Brandt MC,Henn N,Schmidt A,Bloch W,Beuckelmann DJ

更新日期：2001-09-21 00:00:00

abstract：:Adaptation to hypoxia is essential for tumor progression. Transcriptional activation of hypoxia-regulated genes is mediated by hypoxia-inducible factor 1 (HIF-1), a heterodimer of HIF-1alpha and ARNT (Ah receptor nuclear translocator; HIF-1beta). Using representational difference analysis, we identified three novel hy...

journal_title：FEBS letters

authors： Saarikoski ST,Rivera SP,Hankinson O

更新日期：2002-10-23 00:00:00

abstract：:From human PBMC stimulated with PHA, we have isolated cDNA clones encoding a novel cytokine named SCM-1, which is significantly related to the CC and the CXC chemokines but has only the 2nd and the 4th of the four cysteines conserved in these proteins. Its gene is also distinctly mapped to human chromosome 1. SCM-1 is...

journal_title：FEBS letters

authors： Yoshida T,Imai T,Kakizaki M,Nishimura M,Yoshie O

更新日期：1995-02-27 00:00:00

abstract：:U46619 is a potent platelet agonist, its binding to the thromboxane A2 receptor resulting in Gq-binding protein-mediated responses; nevertheless, it is unable to cause platelet aggregation, unless released ADP is present. In this study we demonstrate that Gi activation is the step U46619 lacks to cause platelet aggreg...

journal_title：FEBS letters

authors： Pulcinelli FM,Pesciotti M,Pignatelli P,Riondino S,Gazzaniga PP

更新日期：1998-09-11 00:00:00

abstract：:In Alzheimer disease (AD) the microtubule associated protein (MAP) tau is hyperphosphorylated at several sites. In the present study, like AD tau, tau in the human neuroblastoma SH-SY5Y was found to be hyperphosphorylated, at Ser-199/202, Thr-231, Ser-396 and Ser-404. However, in contrast to AD, the tau in SY5Y cells ...

journal_title：FEBS letters

authors： Tanaka T,Iqbal K,Trenkner E,Liu DJ,Grundke-Iqbal I

更新日期：1995-02-20 00:00:00

abstract：:The insulin receptor family consists of the homologous tyrosine kinase receptors, insulin receptor (IR), insulin-like growth factor 1 receptor (IGF1R) and insulin receptor-related receptor. The three-dimensional structures of the tyrosine kinase domain of the IR and the first three extracellular domains (L1, Cys-rich ...

journal_title：FEBS letters

authors： Marino-Buslje C,Mizuguchi K,Siddle K,Blundell TL

更新日期：1998-12-18 00:00:00

abstract：:Endoplasmic reticulum stress (ER-stress) is associated with ataxia telangiectasia mutated (ATM) gene. We present here conclusive data showing that ATM blocks ER-stress induced by tunicamycin or ionizing radiation (IR). X-box protein-1 (XBP-1) splicing, GRP78 expression and caspase-12 activation were increased by tunic...

journal_title：FEBS letters

authors： He L,Kim SO,Kwon O,Jeong SJ,Kim MS,Lee HG,Osada H,Jung M,Ahn JS,Kim BY

更新日期：2009-03-04 00:00:00

abstract：:The calcitonin receptor (CTR) gene in human osteoclasts formed in a human bone marrow cell culture system was examined by reverse transcription-polymerase chain reaction (RT-PCR). The RT-PCR results indicated that the 5'-untranslated region (5'UTR) was different between CTR mRNAs in human osteoclasts and in a mammary ...

journal_title：FEBS letters

authors： Nishikawa T,Ishikawa H,Yamamoto S,Koshihara Y

更新日期：1999-09-24 00:00:00

abstract：:The function of the amino- and carboxyl-terminal domains of the yeast plasma membrane H+-ATPase have been investigated by constructing deletions in vitro and selectively expressing the mutant enzymes in vivo. The first 27 amino acids are dispensable but deletion of a further 33 amino acids greatly decreases the appear...

journal_title：FEBS letters

authors： Portillo F,de Larrinoa IF,Serrano R

更新日期：1989-04-24 00:00:00

abstract：:Liver microsomes contain a vitamin K and O2-dependent carboxylase that converts peptide-bound glutamyl residues to gamma-carboxyglutamate residues. The peptide Boc-O-phospho-Ser-O-phospho-Ser-Leu-OMe has now been synthesized. This peptide inhibits the carboxylation of endogenous protein precursors by a detergent-solub...

journal_title：FEBS letters

authors： Rich DH,Kawai M,Goodman HL,Engelke J,Suttie JW

更新日期：1983-02-07 00:00:00

abstract：:Using a variety of peptide analogues of oxytocin (OT) and Arg8-vasopressin (AVP), OT-mediated induction of urokinase-type plasminogen activator (uPA) was examined in LLC-PK1 renal epithelial cells, which possess distinct high-affinity receptors of both the OT- and vasopressin renal (V2-) types. OT or OT-receptor speci...

journal_title：FEBS letters

authors： Jans DA,Pavo I,Fahrenholz F

更新日期：1993-01-04 00:00:00

abstract：:Calpastatin molecule contains four repeated inhibition domains, each having highly conserved internal regions A, B and C. The synthetic oligopeptides of regions A and C had no calpain inhibition activity while region B oligopeptide showed weak inhibition activity. Real-time biomolecular interaction analysis using a BI...

journal_title：FEBS letters

authors： Takano E,Ma H,Yang HQ,Maki M,Hatanaka M

更新日期：1995-03-27 00:00:00

abstract：:In this study, we demonstrated that tissue inhibitor of metalloproteinases (TIMP) produced by human bone marrow stromal cell line KM-102 had erythroid-potentiating activity (EPA) which stimulates the proliferation of erythroid progenitor cells. We, then, propose a scheme for the bifunctional role of TIMP/EPA in hemato...

journal_title：FEBS letters

authors： Hayakawa T,Yamashita K,Kishi J,Harigaya K

更新日期：1990-07-30 00:00:00

abstract：:The 3D structure of two unlabeled FK506 analogs, (R)- and (S)-[18-OH]ascomycin, when bound to [U-13C,15N]FKBP were determined by isotope-filtered 2D NMR experiments. The structures for the R and S isomers that bind tightly to FKBP but lack immunosuppressive activity are compared to each other and to the conformation o...

journal_title：FEBS letters

authors： Petros AM,Kawai M,Luly JR,Fesik SW

更新日期：1992-08-24 00:00:00

abstract：:Phosphate triester derivatives of the anti-neoplastic alkyl lyso phospholipid (ALP) have been prepared as novel potential therapeutic agents. In particular, symmetrical phosphate triesters have been prepared, using phosphorochloridate chemistry. The compounds have been fully characterised by a range of techniques, and...

journal_title：FEBS letters

authors： McGuigan C,Wang Y,Riley PA

更新日期：1995-09-25 00:00:00

abstract：:Horseradish peroxidase in the presence of hydrogen peroxide (HRP/H2O2) oxidizes a carcinogenic non-aminoazo dye, 1-phenylazo-2-hydroxynaphthalene (Sudan I) to the ultimate carcinogen, which binds to calf thymus DNA. The principal product of Sudan I oxidation by the HRP/H2O2 system is the benzenediazonium ion. Minor pr...

journal_title：FEBS letters

authors： Stiborová M,Asfaw B,Anzenbacher P

更新日期：1988-05-23 00:00:00