Cyclosporin A inhibits H2O2-induced apoptosis of human fibroblasts.

Abstract:

:Several clinical studies have shown that cyclosporin A (CsA) is effective for treating a variety of chronic inflammatory and autoimmune diseases. Because reactive oxygen species are believed to play a key role in the development of these diseases, causing cell apoptosis, we investigated whether CsA inhibits H2O2-induced apoptosis. Preincubation of human fibroblasts with CsA dose-dependently decreased H2O2-induced apoptosis. Apoptosis suppression by CsA was correlated with the prevention of mitochondrial dysfunction and caspase activation. Thus, our results suggest that the inhibition of apoptosis by CsA may at least partly contribute to the anti-inflammatory effect of CsA.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Sugano N,Ito K,Murai S

doi

10.1016/s0014-5793(99)00312-9

keywords:

subject

Has Abstract

pub_date

1999-03-26 00:00:00

pages

274-6

issue

2-3

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(99)00312-9

journal_volume

447

pub_type

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