Cyclosporin A inhibits H2O2-induced apoptosis of human fibroblasts.


:Several clinical studies have shown that cyclosporin A (CsA) is effective for treating a variety of chronic inflammatory and autoimmune diseases. Because reactive oxygen species are believed to play a key role in the development of these diseases, causing cell apoptosis, we investigated whether CsA inhibits H2O2-induced apoptosis. Preincubation of human fibroblasts with CsA dose-dependently decreased H2O2-induced apoptosis. Apoptosis suppression by CsA was correlated with the prevention of mitochondrial dysfunction and caspase activation. Thus, our results suggest that the inhibition of apoptosis by CsA may at least partly contribute to the anti-inflammatory effect of CsA.




FEBS letters


Sugano N,Ito K,Murai S





Has Abstract


1999-03-26 00:00:00














  • A novel antimicrobial peptide from the loach, Misgurnus anguillicaudatus.

    abstract::A novel antimicrobial peptide, named misgurin, was isolated and characterized from the loach (mudfish), Misgurnus anguillicaudatus. The 21-amino-acid peptide with a molecular mass of 2502 Da was purified to homogeneity using a heparin-affinity column and C18 reverse-phase and gel-permeation high-performance liquid chr...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Park CB,Lee JH,Park IY,Kim MS,Kim SC

    更新日期:1997-07-14 00:00:00

  • A unified framework for unraveling the functional interaction structure of a biomolecular network based on stimulus-response experimental data.

    abstract::We propose a unified framework for the identification of functional interaction structures of biomolecular networks in a way that leads to a new experimental design procedure. In developing our approach, we have built upon previous work. Thus we begin by pointing out some of the restrictions associated with existing s...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Cho KH,Choo SM,Wellstead P,Wolkenhauer O

    更新日期:2005-08-15 00:00:00

  • Cholesterol uptake of isolated rat hepatocytes is accelerated by several kinds of phosphatidylcholine.

    abstract::Uptake of cholesterol by isolated rat hepatocytes in a serum-free medium was remarkably enhanced by dispersion with several kinds of phosphatidylcholine. Of the various phosphatidylcholines tested, dilinoylphosphatidylcholine had the strongest accelerating effect, while dipalmitoylphosphatidylcholine was the weakest. ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Nagamura Y,Sasaki K,Ito M,Saito K,Ogitsu N,Ishiguro I

    更新日期:1986-07-14 00:00:00

  • A potential biochemical explanation for the genesis of porphyria cutanea tarda. Studies on the inherent biochemical defect in highly purified human erythrocyte uroporphyrinogen decarboxylase and its amplification by iron.

    abstract::Familial porphyria cutanea tarda (PCT) is a photocutaneous disease in which subnormal activity of uroporphyrinogen decarboxylase is observed both in the liver and red cells. Hepatic iron plays a key role in the genesis of overt biochemical and clinical PCT. In this report, we have studied the properties of 10 000-fold...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Mukerji SK,Pimstone NR,Tan KT

    更新日期:1985-09-23 00:00:00

  • The first plant type III polyketide synthase that catalyzes formation of aromatic heptaketide.

    abstract::A cDNA encoding a novel plant type III polyketide synthase (PKS) was cloned from rhubarb (Rheum palmatum). A recombinant enzyme expressed in Escherichia coli accepted acetyl-CoA as a starter, carried out six successive condensations with malonyl-CoA and subsequent cyclization to yield an aromatic heptaketide, aloesone...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Abe I,Utsumi Y,Oguro S,Noguchi H

    更新日期:2004-03-26 00:00:00

  • Calcium-dependent binding of uteroglobin (PCB-BP/CCSP) to negatively charged phospholipid liposomes.

    abstract::To investigate interactions between the polychlorinated biphenyl-binding protein uteroglobin and phospholipids, we used a liposome-pelletting assay. PCB-BP/uteroglobin bound to liposomes made from negatively charged phospholipids (PtdSer and PtdIns) in the presence of 5 mM calcium. No binding to liposomes made from ph...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Nord M,Gustafsson JA,Lund J

    更新日期:1995-11-06 00:00:00

  • Formation of free sphingosine and ceramide from exogenous ganglioside GM1 by cerebellar granule cells in culture.

    abstract::Cerebellar granule cells differentiated in culture were incubated with ganglioside [3H-Sph]GM1 in order to have it inserted into the plasma membrane and metabolized. Among the formed metabolites radioactive sphingosine and ceramide were identified. [3H]Ceramide started to be measurable after 10 min of incubation (puls...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Riboni L,Bassi R,Sonnino S,Tettamanti G

    更新日期:1992-03-30 00:00:00

  • Purification of a putative Na+/D-glucose cotransporter from pig kidney brush border membranes on a phlorizin affinity column.

    abstract::Phlorizin, a potent inhibitor of the Na+/D-glucose cotransporter, was derivatised to 3-aminophlorizin and subsequently coupled to Affi-Gel 15. Affinity chromatography of pig kidney brush border membranes solubilised in Triton X-100 allowed the purification of a 60 kDa protein on this resin. We consider this protein to...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kitlar T,Morrison AI,Kinne R,Deutscher J

    更新日期:1988-07-04 00:00:00

  • Post-genomic insight into thylakoid membrane lateral heterogeneity and redox balance.

    abstract::Photosynthetic machinery requires balanced distribution of excitation energy from the light-harvesting complexes to photosystems. The efficiency of light-harvesting is regulated by thermal dissipation of excess energy, while the distribution of energy between photosystems is dependent on STN7 kinase and phosphorylatio...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Tikkanen M,Suorsa M,Gollan PJ,Aro EM

    更新日期:2012-08-31 00:00:00

  • The antioxidative function of eicosapentaenoic acid in a marine bacterium, Shewanella marinintestina IK-1.

    abstract::When the eicosapentaenoic acid (EPA)-deficient mutant strain IK-1Delta8 of the marine EPA-producing Shewanella marinintestina IK-1 was treated with various concentrations of hydrogen peroxide (H(2)O(2)), its colony-forming ability decreased more than that of the wild type. Protein carbonylation, induced by treating ce...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Nishida T,Morita N,Yano Y,Orikasa Y,Okuyama H

    更新日期:2007-09-04 00:00:00

  • Imaging the assembly and disassembly kinetics of cis-SNARE complexes on native plasma membranes.

    abstract::Mild sonication of eukaryotic cells produces native plasma membrane sheets that retain their docked organelles, cytoskeleton structures and cytoplasmic complexes. While the delicate organization of membranous protein complexes remains undisturbed, their inner plasmalemmel leaflet can be rapidly exposed to bathing solu...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Bar-On D,Winter U,Nachliel E,Gutman M,Fasshauer D,Lang T,Ashery U

    更新日期:2008-10-15 00:00:00

  • Label-free optical biosensor with microfluidics for sensing ligand-directed functional selectivity on trafficking of thrombin receptor.

    abstract::Ligand-directed functional selectivity has stimulated much interest in the molecular delineation of drug pharmacology and the process of drug discovery. Here we describe the development of a label-free optical biosensor with microfluidics for whole cell sensing. The microfluidics controls the duration of agonist expos...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Goral V,Wu Q,Sun H,Fang Y

    更新日期:2011-04-06 00:00:00

  • Outer membrane protein A of Escherichia coli forms temperature-sensitive channels in planar lipid bilayers.

    abstract::The temperature dependence of single-channel conductance and open probability for outer membrane protein A (OmpA) of Escherichia coli were examined in planar lipid bilayers. OmpA formed two interconvertible conductance states, small channels, 36-140 pS, between 15 and 37 degrees C, and large channels, 115-373 pS, betw...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Zakharian E,Reusch RN

    更新日期:2003-12-04 00:00:00

  • Insertional inactivation of the psbO gene encoding the manganese stabilizing protein of photosystem II in the cyanobacterium Synechococcus PCC7942. Effect on photosynthetic water oxidation and L-amino acid oxidase activity.

    abstract::A Synechococcus PCC7942 mutant in which the psbO gene was inactivated by insertion of a chloramphenicol interposon and which did not contain any detectable manganese stabilizing protein in immunoblot experiments, was constructed. Such a Synechococcus mutant was able to grow under photoautotrophic conditions. Isolated ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Bockholt R,Masepohl B,Pistorius EK

    更新日期:1991-12-02 00:00:00

  • The effect of local anaesthetics on the ryanodine receptor/Ca2+ release channel of brain microsomal membranes.

    abstract::The effects of various local anaesthetics (LAs) on ryanodine binding of the sheep brain ryanodine receptor were tested. Tetracaine and dibucaine inhibit the binding with half-maximal inhibition (CI50) of 0.12 mM and 0.7 mM, respectively. Lidocaine and its analog QX-314, on the other hand, stimulate the binding up to 3...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Martin C,Ashley R,Shoshan-Barmatz V

    更新日期:1993-08-09 00:00:00

  • Influenza A virus-induced caspase-3 cleaves the histone deacetylase 6 in infected epithelial cells.

    abstract::Histone deacetylase 6 (HDAC6) is a multi-substrate cytoplasmic enzyme that regulates many important biological processes. Recently, some reports have implicated HDAC6 in viral infection. However, nothing is known about its regulation in virus-infected cells. The data presented here for the first time demonstrate the c...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Husain M,Harrod KS

    更新日期:2009-08-06 00:00:00

  • Comparative optically detected magnetic resonance studies of mammalian phospholipase A2-lipid interactions.

    abstract::A major difference between porcine and bovine pancreatic phospholipase A2 (PA2) is the relatively low affinity of the bovine enzyme for lipid-water interfaces. We have investigated the binding of porcine, bovine, and equine PA2 to n-hexadecylphosphocholine (C16-PC) micelles using optically detected magnetic resonance ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Mao SY,Maki AH,de Haas GH

    更新日期:1987-01-19 00:00:00

  • The C-A mismatch base pair and the single-strand terminus in the E. coli initiator tRNA(fMet) acceptor stem adopt unusual conformations.

    abstract::Acceptor stem variants of tRNA(fMet) (Escherichia coli) have been characterized by nuclear magnetic resonance. The wild type contains a C1-A72 mismatch pair which is crucial for its biological function. For comparison, the mismatch was replaced by regular pairs U1-A72 and C1-G72. Further variants contain an altered di...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Zuleeg T,Vogtherr M,Schübel H,Limmer S

    更新日期:2000-04-28 00:00:00

  • The cDNA of the two isoforms of bovine cGMP-dependent protein kinase.

    abstract::cDNAs encoding the isoform I alpha of the cGMP-dependent protein kinase were isolated from a bovine trachea smooth muscle cDNA library constructed in lambda gt10. The deduced protein sequence is identical with the protein sequence obtained by Edman degradation of the bovine lung enzyme [(1984) Biochemistry 23, 4207-42...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Wernet W,Flockerzi V,Hofmann F

    更新日期:1989-07-17 00:00:00

  • Attenuation of fibroblast growth factor signaling by poly-N-acetyllactosamine type glycans.

    abstract::Fibroblast growth factors (FGFs) and their receptors are expressed in a variety of mammalian tissues, playing a role in development and cell proliferation. While analyzing human sperm motility, we found that sperm treated with endo-β-galactosidase (EBG), which specifically hydrolyzes poly-N-acetyllactosamine type glyc...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Sugihara K,Shibata TK,Takata K,Kimura T,Kanayama N,Williams R,Hatakeyama S,Akama TO,Kuo CW,Khoo KH,Fukuda MN

    更新日期:2013-10-01 00:00:00

  • Active transport of lead by human red blood cells.

    abstract::Human red cells suspended in lead-citrate buffers (2.6 microM Pb2+) take up much less Pb than predicted from studies of equilibrium binding of Pb to haemolysates. Pb uptake is increased by ATP depletion, or by loading at 0 degrees C. Tracer studies with 203Pb indicate that the low uptake at 37 degrees C in the presenc...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Simons TJ

    更新日期:1984-07-09 00:00:00

  • Amiloride at pH 7.0 inhibits the Na(+)-driven flagellar motors of Vibrio alginolyticus but allows cell growth.

    abstract::Amiloride, a specific inhibitor for the Na(+)-driven flagellar motors of alkalophilic Bacillus, is known to inhibit secondarily the growth of alkalophiles. The motility of a marine Vibrio, V. alginolyticus, was almost completely inhibited by 2 mM amiloride either at pH 7.0 or 8.5. We found that this concentration of a...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Atsumi T,Maekawa Y,Tokuda H,Imae Y

    更新日期:1992-12-14 00:00:00

  • The ubiquitin ligase gene (WWP1) is responsible for the chicken muscular dystrophy.

    abstract::Chicken muscular dystrophy with abnormal muscle (AM) has been studied for more than 50 years, but the gene responsible for it remains unclear. Our previous studies narrowed down the AM candidate region to approximately 1Mbp of chicken chromosome 2q containing seven genes. In this study, we performed sequence compariso...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Matsumoto H,Maruse H,Inaba Y,Yoshizawa K,Sasazaki S,Fujiwara A,Nishibori M,Nakamura A,Takeda S,Ichihara N,Kikuchi T,Mukai F,Mannen H

    更新日期:2008-06-25 00:00:00

  • Protein transport via the cpTat pathway displays cooperativity and is stimulated by transport-incompetent substrate.

    abstract::Kinetic analyses of cpTat-mediated protein transport across the thylakoid membrane were conducted, revealing three important characteristics of this translocation pathway. First, transport via the cpTAT system displays a non-Michaelis-Menten, sigmoidal rate-substrate relationship with an apparent Hill coefficient of 1...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Alder NN,Theg SM

    更新日期:2003-04-10 00:00:00

  • Knockdown of aquaporin 3 is involved in intestinal barrier integrity impairment.

    abstract::AQP3 is a water/glycerol transporter expressed at the basolateral membrane of colonic epithelial cells. Although AQPs are expressed in the gastrointestinal tract, their effect on intestinal barrier has not been clear. Here, we showed that knockdown of AQP3 caused a dramatic, dose-dependent increase in E. coli C25 tran...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Zhang W,Xu Y,Chen Z,Xu Z,Xu H

    更新日期:2011-10-03 00:00:00

  • Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1.

    abstract::cDNA for a novel proton/organic cation transporter, OCTN1, was cloned from human fetal liver and its transport activity was investigated. OCTN1 encodes a 551-amino acid protein with 11 transmembrane domains and one nucleotide binding site motif. It is strongly expressed in kidney, trachea, bone marrow and fetal liver ...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Tamai I,Yabuuchi H,Nezu J,Sai Y,Oku A,Shimane M,Tsuji A

    更新日期:1997-12-08 00:00:00

  • Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits.

    abstract::The acronym CK2 denotes a highly pleiotropic Ser/Thr protein kinase whose over-expression correlates with neoplastic growth. A vexed question about the enigmatic regulation of CK2 concerns the actual existence in living cells of the catalytic (alpha and/or alpha') and regulatory beta-subunits of CK2 not assembled into...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Salvi M,Sarno S,Marin O,Meggio F,Itarte E,Pinna LA

    更新日期:2006-07-10 00:00:00

  • Reversible unfolding of dimeric phosphofructokinase-2 from Escherichia coli reveals a dominant role of inter-subunit contacts for stability.

    abstract::Escherichia coli phosphofructokinase-2 (Pfk-2) is a homodimer whose subunits consist of a large domain and an additional beta-sheet that provides the interfacial contacts between the subunits, creating a beta-barrel flattened-like structure with the adjacent subunit's beta-sheet. To determine how the structural organi...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Baez M,Babul J

    更新日期:2009-06-18 00:00:00

  • Cbl-b-dependent degradation of FLIP(L) is involved in ATO-induced autophagy in leukemic K562 and gastric cancer cells.

    abstract::Various molecular mechanisms are involved in the efficacy of arsenic trioxide (ATO) against malignant hematologic and some solid tumors. FLICE-like inhibitory protein (FLIP) is an inhibitor of apoptosis mediated by death receptors. In this study, we identified a new link between the down-regulation of cellular FLIP(L)...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Zhang G,Liu J,Zhang Y,Qu J,Xu L,Zheng H,Liu Y,Qu X

    更新日期:2012-09-21 00:00:00

  • Simplicity in complexity: the photosynthetic reaction center performs as a simple 0.2 V battery.

    abstract::The photosynthetic reaction center is one of the most complicated molecular complexes. Transducing photon energy to a transmembrane electrochemical potential difference for protons, it is the direct or indirect energy source for virtually all life. We show here that it operates in a simple, battery-like manner, with a...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: van Rotterdam BJ,Crielaard W,van Stokkum IH,Hellingwerf KJ,Westerhoff HV

    更新日期:2002-01-02 00:00:00