Aloe emodin glycosides stimulates glucose transport and glycogen storage through PI3K dependent mechanism in L6 myotubes and inhibits adipocyte differentiation in 3T3L1 adipocytes.

abstract：:It is now widely recognized that the packaging of genomic DNA, together with core histones, linker histones, and other functional proteins into chromatin profoundly influences nuclear processes such as transcription, replication, DNA repair, and recombination. Whereas earlier structural studies portrayed nucleosomes (...

journal_title：FEBS letters

authors： Chakravarthy S,Park YJ,Chodaparambil J,Edayathumangalam RS,Luger K

更新日期：2005-02-07 00:00:00

abstract：:Initiation of translation in hepatitis C virus (HCV) is dependent on the presence of an internal ribosome entry site (IRES) contained in its 341-nt-long 5'-untranslated region (UTR). This region is very conserved among different isolates and has been used to classify HCV isolates in six different genotypes. These geno...

journal_title：FEBS letters

authors： Buratti E,Gerotto M,Pontisso P,Alberti A,Tisminetzky SG,Baralle FE

更新日期：1997-07-14 00:00:00

abstract：:In the present study, we have explored the impact of deleting a single allele of PDK1 in T cell progenitors on alpha/beta and gamma/delta T cell development. The data show that deleting a single allele of PDK1 allows differentiation of alpha/beta T cells but prevents their proliferative expansion in the thymus. Accord...

journal_title：FEBS letters

authors： Kelly AP,Hinton HJ,Clarke RG,Cantrell DA

更新日期：2006-04-03 00:00:00

abstract：:To obtain information on the biological significance of yeast fructose-2,6-bisphosphate 6-phosphatase, kinetic data of the purified enzyme [(1987) Eur. J. Biochem. 164, 27-30] have been measured. Maximal activity was found between pH 6 and 7, the apparent Michaelis constant with fructose 2,6-bisphosphate was 7.2 micro...

journal_title：FEBS letters

authors： Plankert U,Purwin C,Holzer H

更新日期：1988-10-24 00:00:00

abstract：:We have attempted to elucidate the mechanism of apoptotic cell death induced by hypoxia (very low oxygen conditions) in neuronal cells. Human neuroblastoma SK-N-MC cells under hypoxic conditions resulted in apoptosis in a time-dependent manner estimated by DNA fragmentation assay and nuclear morphology stained with fl...

journal_title：FEBS letters

authors： Araya R,Uehara T,Nomura Y

更新日期：1998-11-13 00:00:00

abstract：:Human seminal fluid contains a number of tripeptide amides with similar structures to thyrotropin releasing hormone (TRH), two of which have been identified as pGlu-Glu-Pro amide and pGlu-Phe-Pro amide. To determine whether these peptides originate in the same tissues and have the same molecular origin, TRH-immunoreac...

journal_title：FEBS letters

authors： Linden H,del Rio Garcia J,Huber A,Kreil G,Smyth D

更新日期：1996-01-22 00:00:00

abstract：:In mammalian cells, the Bcl-2 and Bcl-x(L) proteins suppress programmed cell death whereas the topographically similar Bax protein accelerates the apoptotic process. Recently published data suggest that expression of the human Bax-alpha gene is lethal for the yeast Saccharomyces cerevisiae and that this toxicity can b...

journal_title：FEBS letters

authors： Greenhalf W,Stephan C,Chaudhuri B

更新日期：1996-02-12 00:00:00

abstract：:We have investigated the possible role of selected negatively-charged amino acids of the sodium and chloride-coupled GABA transporter GAT-1 on sodium binding. These residues located adjacent to putative transmembrane domains and which are conserved throughout the large superfamily of neurotransmitter transporters were...

journal_title：FEBS letters

authors： Keshet GI,Bendahan A,Su H,Mager S,Lester HA,Kanner BI

更新日期：1995-08-28 00:00:00

abstract：:We have recently cloned a cDNA encoding sucrose:fructan 6-fructosyltransferase (6-SFT), a key enzyme of fructan synthesis forming the beta-2,6 linkages typical of the grass fructans, graminans and phleins [Sprenger et al. (1995) Proc. Natl. Acad. Sci. USA 92, 11652-11656]. Here we report functional expression of 6-SFT...

journal_title：FEBS letters

authors： Sprenger N,Schellenbaum L,van Dun K,Boller T,Wiemken A

更新日期：1997-01-06 00:00:00

abstract：:Exposing a macrophage-like murine cell line to copper-oxidised low-density lipoprotein led to DNA fragmentation which was inhibited by the putative Ca2+/Mg2+ endonuclease inhibitor, zinc sulphate. DNA fragmentation preceded loss of membrane impermeability. These results suggest that apoptosis may be a mechanism of mac...

journal_title：FEBS letters

authors： Reid VC,Hardwick SJ,Mitchinson MJ

更新日期：1993-10-18 00:00:00

abstract：:We previously reported that daily intraperitoneal injections of oleamide weakly inhibits the spontaneous metastasis of BL6 cells by blocking the gap junction-mediated intercellular communications (GJIC) of connexin 26 (Cx26). In the present study, we tested camellia oil, olive oil and cottonseed oil which are rich in ...

journal_title：FEBS letters

authors： Miura D,Kida Y,Nojima H

更新日期：2007-05-29 00:00:00

abstract：:Long-chain fatty acid amides are cell-signaling lipids identified in mammals and, recently, in invertebrates, as well. Many details regarding fatty acid amide metabolism remain unclear. Herein, we demonstrate that Drosophila melanogaster is an excellent model system for the study long-chain fatty acid amide metabolism...

journal_title：FEBS letters

authors： Jeffries KA,Dempsey DR,Behari AL,Anderson RL,Merkler DJ

更新日期：2014-05-02 00:00:00

abstract：:The pl6INK4a tumor suppressor negatively regulates progression through the G1 phase of the mammalian cell cycle. To mimic the downmodulation of p16INK4a commonly seen in cancer, we designed and characterized a hammerhead ribozyme against exon E1alpha of the murine pl6INK4a transcript. Stable expression of the ribozyme...

journal_title：FEBS letters

authors： Nylandsted J,Rohde M,Bartek J,Strauss M

更新日期：1998-09-25 00:00:00

abstract：:Phosphorylation of H2AX is believed to be associated with the repair of damaged DNA. Recent findings suggest a novel function of H2AX in cellular apoptosis. Specifically, it was shown that ultraviolet A-activated JNK phosphorylates H2AX to regulate apoptosis. Here we show that serum starvation induces H2AX phosphoryla...

journal_title：FEBS letters

authors： Lu C,Shi Y,Wang Z,Song Z,Zhu M,Cai Q,Chen T

更新日期：2008-08-06 00:00:00

abstract：:Plasmids for the high-level overproduction of wild-type, and C- and N-terminal His-tagged MurG N-acetylglucosaminyl transferase from Escherichia coli were constructed. In complementation tests the three forms were active in vivo. After IPTG induction, growth, spheroplast formation and lysis, overproduced MurG proteins...

journal_title：FEBS letters

authors： Crouvoisier M,Mengin-Lecreulx D,van Heijenoort J

更新日期：1999-04-23 00:00:00

abstract：:We have generated a mouse model for hepatic ischemia in which surgical subcutaneous transposition of the spleen allows hepatic ischemia to be applied without affecting other tissues. Using this mouse model we investigated the relationship between the length of ischemic periods in the liver and subsequent liver functio...

journal_title：FEBS letters

authors： Onishi I,Tani T,Hashimoto T,Shimizu K,Yagi M,Yamamoto K,Yoshioka K

更新日期：1997-12-29 00:00:00

abstract：:A chemokine receptor, CXCR4, and its endogenous ligand, stromal cell-derived factor-1 (SDF-1), have been recognized to be involved in the metastasis of several types of cancers. T140 analogs are peptidic CXCR4 antagonists composed of 14 amino acid residues that were previously developed as anti-HIV agents having inhib...

journal_title：FEBS letters

authors： Tamamura H,Hori A,Kanzaki N,Hiramatsu K,Mizumoto M,Nakashima H,Yamamoto N,Otaka A,Fujii N

更新日期：2003-08-28 00:00:00

abstract：:The tropomyosin-related kinase A (TrkA) receptor and its ligand, nerve growth factor (NGF), play crucial roles in the development and function of the nervous system. NGF is believed to activate TrkA by bridging two TrkA monomers, leading to TrkA transphosphorylation. However, here we show that the majority of TrkA rec...

journal_title：FEBS letters

authors： Shen J,Maruyama IN

更新日期：2011-01-21 00:00:00

abstract：:A stable complex of the chaperonins, cpn60 and cpn10 (Escherichia coli GroEL and GroES homologues), from the extremely thermophilic bacterium Thermus thermophilus has been isolated and crystallized. The crystals have dimensions up to 30 x 200 x 200 microns. Ultra-thin sections of the crystals estimated by electron mic...

journal_title：FEBS letters

authors： Lissin NM,Sedelnikova SE,Ryazantsev SN

更新日期：1992-10-12 00:00:00

abstract：:We previously reported that tau protein kinase II (TPKII) from bovine brain was composed of 30 kDa and 23 kDa subunits. The 30 kDa subunit of TPKII can be regarded as a catalytic subunit because of its ATP-binding activity. Antibodies directed against TPKII-phosphorylated tau also reacted with tau phosphorylated by cd...

journal_title：FEBS letters

authors： Kobayashi S,Ishiguro K,Omori A,Takamatsu M,Arioka M,Imahori K,Uchida T

更新日期：1993-12-06 00:00:00

abstract：:The control of physiological processes requires the regulation and coordination of many different signals and is determined in part by the activation and repression of expression of specific target genes. RIP140 is a ligand dependent coregulator of many nuclear receptors that influence such diverse processes as muscle...

journal_title：FEBS letters

authors： White R,Morganstein D,Christian M,Seth A,Herzog B,Parker MG

更新日期：2008-01-09 00:00:00

abstract：:Cholesterol is one of the major lipids of plasma membranes. Recently, we have shown that cholesterol depletion by methyl-beta-cyclodextrin (M beta CD) induces the activation of the Wnt/beta-catenin pathway and enhances myogenic differentiation. Here, we show that M beta CD-conditioned media accelerates myogenesis in a...

journal_title：FEBS letters

authors： Portilho DM,Martins ER,Costa ML,Mermelstein CS

更新日期：2007-12-22 00:00:00

abstract：:Various properties have been evaluated for the binding to tissue culture substrata of proteolytic fragments of human plasma or cellular fibronectins containing complementary sequences from the individual and alternatively spliced chains, since related fragments are known to yield differing adhesive responses from cell...

journal_title：FEBS letters

authors： Lewandowska K,Kaetzel CS,Zardi L,Culp LA

更新日期：1988-09-12 00:00:00

abstract：:A new insertion sequence, IS186, has been identified from Escherichia coli and sequenced. It contains 1336 base pairs with a terminal inverted repeat of 22 nucleotides. A long open reading frame, from an ATG codon at position 55 to a TAG termination codon at 1327, could code for a polypeptide of 424 amino acids. This ...

journal_title：FEBS letters

authors： Chong P,Hui I,Loo T,Gillam S

更新日期：1985-11-11 00:00:00

abstract：:Truncated cyclin A and cyclin B lacking the N-terminal domain comprising the 'destruction box' escape from proteolysis and arrest cells at metaphase. Mutation of a conserved arginine residue of the destruction domain makes cyclin B resistant to proteolysis. Here we show that mutation of the same residue also makes cyc...

journal_title：FEBS letters

authors： Lorca T,Devault A,Colas P,Van Loon A,Fesquet D,Lazaro JB,Dorée M

更新日期：1992-07-13 00:00:00

abstract：:The temperate phage phi H of the extremely halophilic archaebacterium Halobacterium salinarium encodes a repressor, Rep, which in the immune state represses the production of an early lytic transcript, denoted T4. Rep acts at the transcriptional level by blocking the promoter for T4. The promoter for the rep gene itse...

journal_title：FEBS letters

authors： Stolt P,Zillig W

更新日期：1994-05-16 00:00:00

abstract：:A reversible two-step (native state<-->denatured state) folding mechanism based on equilibrium and stopped flow experiments is proposed for urea denaturation of the lipoyl-bearing domain (hbLBD) of human mitochondrial branched chain alpha-ketoacid dehydrogenase (BCKD) complex. The results from this circular dichroism ...

journal_title：FEBS letters

authors： Naik MT,Chang YC,Huang TH

更新日期：2002-10-23 00:00:00

abstract：:The role of Na+/H+ exchange in protein kinase C-mediated effects in platelets was investigated by studying the effect of removal of extracellular Na+ ([Na+]e) on the different responses induced by phorbol 12-myristate 13-acetate (PMA) and 1,2-dioctanoylglycerol (diC8). None of the responses studied, namely, protein ph...

journal_title：FEBS letters

authors： Krishnamurthi S,Patel Y,Morgan WA,Wheeler-Jones CP,Kakkar VV

更新日期：1989-07-31 00:00:00

abstract：:miR398 links expression of the three major chloroplast copper proteins, plastocyanin, CCS1 and Csd2, to copper availability. miR398 abundance was stronger plastocyanin-controlled in accessions from cold and continental habitats (Kas-1, Ms-0, WS) than in Cvi-0 and Col-0. Target gene regulation was broken for Csd2 in Cv...

journal_title：FEBS letters

authors： Juszczak I,Baier M

更新日期：2012-09-21 00:00:00

abstract：:Exposure of a human lung epithelial cancer cell-line to hypo-osmotic media led to a marked increase in the rate of efflux from the cells of taurine, a non-essential sulfonic amino acid. The osmotically-activated taurine efflux was inhibited by a range of known Cl- channel blockers, the most potent of which were NPPB a...

journal_title：FEBS letters

authors： Kirk K,Kirk J

更新日期：1993-12-20 00:00:00