Abstract:
:Exposing a macrophage-like murine cell line to copper-oxidised low-density lipoprotein led to DNA fragmentation which was inhibited by the putative Ca2+/Mg2+ endonuclease inhibitor, zinc sulphate. DNA fragmentation preceded loss of membrane impermeability. These results suggest that apoptosis may be a mechanism of macrophage foam cell death in atherosclerotic lesions in the arterial wall.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Reid VC,Hardwick SJ,Mitchinson MJdoi
10.1016/0014-5793(93)80635-8subject
Has Abstractpub_date
1993-10-18 00:00:00pages
218-20issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(93)80635-8journal_volume
332pub_type
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