Ectodomain shedding of the EGF-receptor ligand epigen is mediated by ADAM17.

Abstract:

:All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are made as transmembrane precursors. Proteolytic processing by ADAMs (a disintegrin and metalloprotease) regulates the bioavailability of several EGFR-ligands, yet little is known about the enzyme responsible for processing the recently identified EGFR ligand, epigen. Here we show that ectodomain shedding of epigen requires ADAM17, which can be stimulated by phorbol esters, phosphatase inhibitors and calcium influx. These results suggest that ADAM17 might be a good target to block the release of bioactive epigen, a highly mitogenic ligand of the EGFR which has been implicated in wound healing and cancer.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Sahin U,Blobel CP

doi

10.1016/j.febslet.2006.11.074

subject

Has Abstract

pub_date

2007-01-09 00:00:00

pages

41-4

issue

1

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(06)01417-7

journal_volume

581

pub_type

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