Abstract:
:Interactions between Trypanosoma cruzi and the extracellular matrix play an important role in cellular invasion. Here we show that T. cruzi increases the levels of thrombospondin-1 (TSP-1) expression in host cells during early infection. Stable RNA interference of host cell TSP-1 knocks down the levels of TSP-1 transcripts and protein expression in mammalian cells causing inhibition of T. cruzi infection. Addition of TSP-1 to these cells restores infection. Thus, host TSP-1, regulated by the parasite, plays a crucial role in early infection. This is the first report showing that a human parasite modulates TSP-1 expression to facilitate infection.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Simmons KJ,Nde PN,Kleshchenko YY,Lima MF,Villalta Fdoi
10.1016/j.febslet.2006.03.054subject
Has Abstractpub_date
2006-04-17 00:00:00pages
2365-70issue
9eissn
0014-5793issn
1873-3468pii
S0014-5793(06)00369-3journal_volume
580pub_type
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