Abstract:
:In this review, we summarize the currently available information on the membrane topology of some key members of the human ABC protein subfamilies, and present the predicted domain arrangements. In the lack of high-resolution structures for eukaryotic ABC transporters this topology is based only on prediction algorithms and biochemical data for the location of various segments of the polypeptide chain, relative to the membrane. We suggest that topology models generated by the available prediction methods should only be used as guidelines to provide a basis of experimental strategies for the elucidation of the membrane topology.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Tusnády GE,Sarkadi B,Simon I,Váradi Adoi
10.1016/j.febslet.2005.11.040keywords:
subject
Has Abstractpub_date
2006-02-13 00:00:00pages
1017-22issue
4eissn
0014-5793issn
1873-3468pii
S0014-5793(05)01403-1journal_volume
580pub_type
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