Abstract:
:Deuterated arachidonic acid (AA, [2H8]20:4 n-6) 1-25 microM, is converted to other fatty acids, as evaluated by gas chromatography-mass spectrometry, in THP-1 cells. The major products, in the 1 to 10 microM range, are 22:4 (elongated) and 20:3 (reduced in 5). At 25 microM, 24:4, 24:5 and 22:5 accumulate, with [2H8]/[2H0] ratios higher than in AA. At high AA concentration preferential conversion to elongated fatty acids with 5 unsaturations, through a 6 desaturase takes place and the 4-desaturated 22:5 appears to be formed through beta-oxidation of 24:5.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Caruso D,Risé P,Galella G,Regazzoni C,Toia A,Galli G,Galli Cdoi
10.1016/0014-5793(94)80554-7subject
Has Abstractpub_date
1994-05-02 00:00:00pages
195-9issue
3eissn
0014-5793issn
1873-3468pii
0014-5793(94)80554-7journal_volume
343pub_type
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