Abstract:
:The mixed lineage kinase (MLK) family is a recently described protein kinase family. The MLKs contain a kinase domain followed by a dual leucine zipper-like motif. We previously reported the molecular cloning of LZK (leucine zipper-bearing kinase), a novel MLK, and that LZK activated the c-Jun NH2 terminal kinase (JNK)/stress-activated protein kinase (SAPK) pathway through MKK7 in cells. Here, we reveal that LZK forms dimers/oligomers through its dual leucine zipper-like motif, and that this is necessary for activation of the JNK/SAPK pathway. We also identify the C-terminal functional region of LZK, which is indispensable for the activation of SEK1, but not that of MKK7.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Ikeda A,Masaki M,Kozutsumi Y,Oka S,Kawasaki Tdoi
10.1016/s0014-5793(00)02432-7keywords:
subject
Has Abstractpub_date
2001-01-19 00:00:00pages
190-5issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(00)02432-7journal_volume
488pub_type
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