Abstract:
:There is evidence that CCK-8 may interact with opioids and that both systems are probably implicated in pain modulation. In order to elucidate this relationship we sought to examine factors governing the movement of CCK-8 from the spinal cord into the extracellular space. We report that CCK-8 like immunoreactivity, as measured by RIA, is released from the spinal cord of the rat in vivo, following potassium stimulation and by direct activation of high threshold peripheral afferents by stimulation of the sciatic nerve. Also, we show that CCK-8 release is inhibited by the mu-selective opioid receptor agonist DAGOL. Naloxone totally reversed the effect produced by DAGOL, implying an opiate mediated mechanism.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rodríguez RE,Sacristán MPdoi
10.1016/0014-5793(89)80723-9subject
Has Abstractpub_date
1989-07-03 00:00:00pages
215-7issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(89)80723-9journal_volume
250pub_type
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