Abstract:
:In mouse mammary epithelial cells in primary culture, mechanical stimulation of a cell induced in other cells within the same colony a short depolarization of less than 15 mV with a duration of 1-8 s and a subsequent, prominent hyperpolarization of 6 mV lasting 10-40 s. Epidermal growth factor induces a spontaneous hyperpolarizing response in cultured mammary cells, and in cells treated with EGF mechanical stimulation produced a greater hyperpolarization, while the amplitude of the depolarizing response was not affected. The amplitude of the mechanically induced hyperpolarization was markedly reduced by quinine and tetraethylammonium, blockers of the Ca2+ -dependent K+ channel. The results suggest that the Ca2+ -dependent K+ channel was involved in the hyperpolarization.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Enomoto K,Furuya K,Maeno T,Edwards C,Oka Tdoi
10.1016/0014-5793(87)80514-8subject
Has Abstractpub_date
1987-10-19 00:00:00pages
82-6issue
1eissn
0014-5793issn
1873-3468journal_volume
223pub_type
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