Abstract:
:Pancreatic islet amyloid is a characteristic feature of type 2 diabetes. The major protein component of islet amyloid is the polypeptide hormone known as islet amyloid polypeptide (IAPP, or amylin). IAPP is stored with insulin in the β-cell secretory granules and is released in response to the stimuli that lead to insulin secretion. IAPP is normally soluble and is natively unfolded in its monomeric state, but forms islet amyloid in type 2 diabetes. Islet amyloid is not the cause of type 2 diabetes, but it leads to β-cell dysfunction and cell death, and contributes to the failure of islet cell transplantation. The mechanism of IAPP amyloid formation is not understood and the mechanisms of cytotoxicity are not fully defined.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Cao P,Marek P,Noor H,Patsalo V,Tu LH,Wang H,Abedini A,Raleigh DPdoi
10.1016/j.febslet.2013.01.046subject
Has Abstractpub_date
2013-04-17 00:00:00pages
1106-18issue
8eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00091-4journal_volume
587pub_type
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