Abstract:
:Treatment of neonatal rat islets of Langerhans with combined cytokines (interleukin-1beta 10(-10) M, tumour necrosis factor-alpha 10(-10) M, interferon-gamma 5 U/ml) led to extensive cell death, which was potentiated by Fas activation with the anti-Fas cytolytic antibody JO2. Pre-treatment with insulin (25 ng/ml) or insulin-like growth factor-1 (10(-8)M) gave only partial protection against cell killing, but prevented the Fas-mediated component. In the absence of cytokine treatment, Fas-mediated killing was not observed.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Harrison M,Dunger AM,Berg S,Mabley J,John N,Green MH,Green ICdoi
10.1016/s0014-5793(98)01051-5subject
Has Abstractpub_date
1998-09-18 00:00:00pages
207-10issue
2-3eissn
0014-5793issn
1873-3468pii
S0014-5793(98)01051-5journal_volume
435pub_type
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