Abstract:
:Large conductance voltage-dependent and Ca(2+)-modulated K(+) channels play a crucial role in myometrium contractility. Western blots and immunocytochemistry of rat uterine sections or isolated cells show that MaxiK channel protein signals drastically decrease towards the end of pregnancy. Consistent with a transcriptional regulation of channel expression, mRNA levels quantified with the ribonuclease protection assay correlated well with MaxiK protein levels. As a control, Na(+)/K(+)-ATPase protein and RNA levels do not significantly change at different stages of pregnancy. The low numbers of MaxiK channels at the end of pregnancy may facilitate uterine contraction needed for parturition.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Song M,Zhu N,Olcese R,Barila B,Toro L,Stefani Edoi
10.1016/s0014-5793(99)01394-0keywords:
subject
Has Abstractpub_date
1999-11-05 00:00:00pages
427-32issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(99)01394-0journal_volume
460pub_type
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