Abstract:
:To clarify the effect of hepatocyte growth factor (HGF) on proliferation of hepatic oval cells, we transferred HGF gene into liver of the Solt-Farber rat model. Male Fisher 344 rats were infected with a recombinant adenovirus carrying the cDNA for HGF (pAxCAHGF) from tail vein. HGF mRNA showed its peak at 4 days, and diminished thereafter. The total and proliferating cell nuclear antigen-positive hepatic oval cells were significantly elevated in HGF-transferred rats, in which stem cell factor and c-kit mRNA increased at each time point. Our results suggest that in vivo transfer of the HGF gene into liver accelerates proliferation of hepatic oval cells in the Solt-Farber model in rats.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Shiota G,Kunisada T,Oyama K,Udagawa A,Nomi T,Tanaka K,Tsutsumi A,Isono M,Nakamura T,Hamada H,Sakatani T,Sell S,Sato K,Ito H,Kawasaki Hdoi
10.1016/s0014-5793(00)01337-5keywords:
subject
Has Abstractpub_date
2000-03-31 00:00:00pages
325-30issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(00)01337-5journal_volume
470pub_type
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