Abstract:
:We describe a Xenopus P2Y receptor that shares only weak homology with members of the mammalian P2Y family, being most similar to human P2Y(11). When activated by nucleotide analogs, it stimulates both calcium and cAMP mobilization pathways, a feature unique, among mammalian P2Y receptors, to P2Y(11). Activity can be blocked by compounds known to act as antagonists of mammalian P2Y(11). Genomic synteny between Xenopus and mammals suggests that the novel gene is a true ortholog of P2Y(11). Xenopus P2Y(11) is transcribed during embryonic development, beginning at gastrulation, and is enriched in the developing nervous system.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Devader C,Drew CM,Geach TJ,Tabler J,Townsend-Nicholson A,Dale Ldoi
10.1016/j.febslet.2007.10.024subject
Has Abstractpub_date
2007-11-13 00:00:00pages
5332-6issue
27eissn
0014-5793issn
1873-3468pii
S0014-5793(07)01083-6journal_volume
581pub_type
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