Molecular and catalytic properties of a peroxiredoxin-glutaredoxin hybrid from Neisseria meningitidis.

abstract：:Cell-substratum adhesion of rat hepatocytes was inhibited by antisera raised against plasma membranes of liver (anti-liver antiserum) and Morris hepatoma 7777 (anti-hepatoma antiserum). Similar concentrations of both antisera inhibited adhesion on collagen. Anti-liver antiserum also inhibited the adhesion of hepatocyt...

journal_title：FEBS letters

authors： Neumeier R,Dethlefs U,Reutter W

更新日期：1984-03-26 00:00:00

abstract：:Our previous study documented the expression of Mta1 during spermatogenesis. Here, we present evidence for a possible involvement of Mta1 in the regulation of testicular function, possibly by interacting with p53. A notable decrease of Mta1 expression was revealed at postsurgical day 6, consistent with the previously ...

journal_title：FEBS letters

authors： Li W,Bao W,Ma J,Liu X,Xu R,Wang RA,Zhang Y

更新日期：2008-03-19 00:00:00

abstract：:Tau proteins aggregate into different neuronal inclusions in several neurodegenerative disorders. In Alzheimer's disease (AD), hyperphosphorylated Tau from paired helical filaments (PHF) of neurofibrillary tangles, named PHF-Tau, have an electrophoretic profile with four main bands (Tau 55, 64, 69, 74 kDa). In Pick's ...

journal_title：FEBS letters

authors： Sergeant N,David JP,Lefranc D,Vermersch P,Wattez A,Delacourte A

更新日期：1997-08-04 00:00:00

abstract：:We present here a combined GC-MS and LC-MS metabolic profiling approach to unraveling the pathological outcomes of aristolochic acid (AA)-induced nephrotoxicity. Urine samples were analyzed by GC-MS and LC-MS in combination with pattern recognition techniques, e.g. principal component analysis (PCA), orthogonal projec...

journal_title：FEBS letters

authors： Ni Y,Su M,Qiu Y,Chen M,Liu Y,Zhao A,Jia W

更新日期：2007-02-20 00:00:00

abstract：:Several studies have indicated the existence of direct effects of melatonin on platelets. Here we show that, melatonin at high concentration is capable of significantly raising platelet intracellular calcium even in the absence of an agonist. The effect of melatonin on platelets was abolished by luzindole, a melatonin...

journal_title：FEBS letters

authors： Kumari S,Dash D

更新日期：2011-07-21 00:00:00

abstract：:The gap junctional intercellular communication mediated by Cx43 plays indispensable roles in both germ line development and postnatal folliculogenesis. In this study, we focused on the effect of follicle-stimulating hormone (FSH) on the Cx43 protein in rat primary granulosa cells and found that FSH stimulation elevate...

journal_title：FEBS letters

authors： Yogo K,Ogawa T,Akiyama M,Ishida N,Takeya T

更新日期：2002-11-06 00:00:00

abstract：:We recently purified two closely related 33 kDa proteins from rat hepatic cytosol, designated bile acid binder I and II, which selectively bind bile acids with comparable affinity as glutathione S-transferase B. This work has now been extended to human liver in which we have identified a similar cytosolic binding acti...

journal_title：FEBS letters

authors： Stolz A,Sugiyama Y,Kuhlenkamp J,Kaplowitz N

更新日期：1984-11-05 00:00:00

abstract：:The role of TlyA, TlyB and TlyC proteins in the biology of Leptospira is still uncertain. Although these proteins have been considered as putative hemolysins, we demonstrate that leptospiral recombinant TlyB and TlyC do not possess hemolytic activity. However, further experiments showed that TlyC is a surface-exposed ...

journal_title：FEBS letters

authors： Carvalho E,Barbosa AS,Gómez RM,Cianciarullo AM,Hauk P,Abreu PA,Fiorini LC,Oliveira ML,Romero EC,Gonçales AP,Morais ZM,Vasconcellos SA,Ho PL

更新日期：2009-04-17 00:00:00

abstract：:The temperature dependence of the rate constants of the univalent redox steps YzoxSi----YzSi + 1 (i = 0,1,2) and YzoxS3----(YzS4)----YzSo + O2 in the water oxidase was investigated by measuring time resolved absorption changes at 355 nm induced by a laser flash train in dark adapted PS II membrane fragments from spina...

journal_title：FEBS letters

authors： Renger G,Hanssum B

更新日期：1992-03-24 00:00:00

abstract：:LEA (late embryogenesis abundant) proteins are intrinsically disordered proteins that contribute to stress tolerance in plants and invertebrates. Here we show that, when both plant and animal LEA proteins are co-expressed in mammalian cells with self-aggregating polyglutamine (polyQ) proteins, they reduce aggregation ...

journal_title：FEBS letters

authors： Liu Y,Chakrabortee S,Li R,Zheng Y,Tunnacliffe A

更新日期：2011-02-18 00:00:00

abstract：:In a subset of olfactory epithelium the odorant receptor guanylate cyclase, ONE-GC, is a central transduction component of the cyclic GMP signaling pathway. The odorant binds to the extracellular domain and activates its intracellular catalytic domain to generate the odorant second messenger, cyclic GMP. The present s...

journal_title：FEBS letters

authors： Duda T,Sharma RK

更新日期：2009-04-17 00:00:00

abstract：:Crk and CrkL adaptors play essential neuronal positioning roles downstream of Reelin-induced Dab1 tyrosine phosphorylation. Recently we identified Cin85 to be a CrkL-SH3 binding partner from embryonic murine brain while others found Cin85 binds directly to Dab1. Here using mass spectrometry, biochemical and mutational...

journal_title：FEBS letters

authors： Bior BK,Ballif BA

更新日期：2013-01-04 00:00:00

abstract：:A mixture of 55 and 53 kDa boar proacrosins was autoactivated at pH 8.5 to produce a 43 kDa intermediate form and a 35 kDa mature acrosin, and each of four forms of (pro)acrosins was isolated. Analysis of the N-terminal sequences of the two proacrosins indicated the existence of a segment corresponding to the acrosin ...

journal_title：FEBS letters

authors： Baba T,Michikawa Y,Kawakura K,Arai Y

更新日期：1989-02-13 00:00:00

abstract：:A large number of protein-protein interactions involved turn or loop regions. The excised linear peptides from these regions reveal complex conformational averaging. To circumvent this motional averaging and to stabilize the beta-turn conformation, extensive effort has been devoted to the design of constrained peptido...

journal_title：FEBS letters

authors： Lee MS,Gardner B,Kahn M,Nakanishi H

更新日期：1995-02-13 00:00:00

abstract：:Meprin α and β, members of the astacin family of zinc metalloproteinases, are unique plasma membrane and secreted proteases known to cleave a wide range of biological substrates involved in inflammation, cancer and fibrosis. In this study, we identified proMMP-9 as a novel substrate and show that aminoterminal meprin-...

journal_title：FEBS letters

authors： Geurts N,Becker-Pauly C,Martens E,Proost P,Van den Steen PE,Stöcker W,Opdenakker G

更新日期：2012-12-14 00:00:00

abstract：:The sarcoplasmic reticulum-bound creatine kinase from rabbit skeletal muscle was inhibited by the nitric oxide donor S-nitrosoglutathione (GSNO). This led to a decrease in Ca2+ uptake in sarcoplasmic reticulum vesicles when the transport was driven by ATP generated from phosphocreatine and ADP. In contrast, the Ca 2+ ...

journal_title：FEBS letters

authors： Wolosker H,Panizzutti R,Engelender S

更新日期：1996-09-02 00:00:00

abstract：:alpha-1-Antitrypsin is found in hepatocytes as a high-mannose glycoprotein (Mr 49 000), extracellularly as a complex-type glycoprotein (Mr 54 000). Deglycosylation of both forms with peptide: N-glycosidase led to proteins of identical app. Mr (41 000). The sequence of 26 N-terminal amino acids of rat alpha 1-antitryps...

journal_title：FEBS letters

authors： Gross V,Kaiser C,Tran-Thi TA,Schmelzer E,Witt I,Plummer TH Jr,Heinrich PC

更新日期：1983-01-24 00:00:00

abstract：:In a wild-type strain of Saccharomyces cerevisiae, cadmium induces the activities of both gamma-glutamyl transferase (gamma-GT) and glutathione transferase 2 (Gtt2). However, Gtt2 activity did not increase under gamma-GT or Ycf1 deficiencies, suggesting that the accumulation of glutathione-cadmium in the cytosol inhib...

journal_title：FEBS letters

authors： Adamis PD,Mannarino SC,Eleutherio EC

更新日期：2009-05-06 00:00:00

abstract：:Tau proteins are abnormally phosphorylated in Alzheimer's disease. Pathological Tau proteins named PHF-Tau 55, PHF-Tau 64, and PHF-Tau 69, are the main constituents of the paired helical filaments (PHF). When treating SKNSH-SY 5Y cells with okadaic acid (OA), Tau 55 protein was clearly induced whereas Tau 64 protein w...

journal_title：FEBS letters

authors： Dupont-Wallois L,Sautière PE,Cocquerelle C,Bailleul B,Delacourte A,Caillet-Boudin ML

更新日期：1995-01-03 00:00:00

abstract：:In the present work, a new endopin-like serpin designed mEndopin 1B was purified from bovine muscle. Biochemical characterizations (amino acid sequencing and Maldi-Tof mass spectrometry peptide mapping) demonstrated that the purified protein is different from the previously described Endopin 1, renamed mEndopin 1A. Th...

journal_title：FEBS letters

authors： Herrera-Mendez CH,Brémaud L,Coulis G,Pélissier P,Sentandreu MA,Aubry L,Delourme D,Chambon C,Maftah A,Leveziel H,Ouali A

更新日期：2006-06-12 00:00:00

abstract：:We have used HPLC techniques to investigate the effects of gp120 upon inositol phosphate turnover in Jurkat E6-1 CD4+ T-cells, to pursue previous reports that this viral coat protein: (a) inhibits receptor-activated inositol phosphate release; (b) stimulates basal inositol phosphate release; (c) inhibits inositol poly...

journal_title：FEBS letters

authors： Sumner MT,Shears SB

更新日期：1997-08-11 00:00:00

abstract：:A variant form of the heptacosapeptide amide secretin, with C-terminal -Val-Gly-Lys-Arg instead of valine amide, has been isolated from porcine upper intestinal tissue. Unexpectedly, this triacontapeptide exhibited a substantially higher bioactivity than the heptacosapeptide amide. ...

journal_title：FEBS letters

authors： Gafvelin G,Carlquist M,Mutt V

更新日期：1985-05-20 00:00:00

abstract：:Hepatitis C virus (HCV) often establishes a persistent infection that leads to chronic liver diseases. The viral core protein modulates various cellular activities involved in this process. We found two mutations, K23E and V31A, in the core gene of the transfected HCV JFH-1 genome, which had been replicated for a prol...

journal_title：FEBS letters

authors： Kang JI,Kwon YC,Ahn BY

更新日期：2012-05-07 00:00:00

abstract：:Recent studies indicate that junctophilin (JP) subtypes contribute to the formation of the junctional membrane complexes between the plasma membrane and the endoplasmic/sarcoplasmic reticulum (ER/SR) in excitable cells. Cardiac muscle contains the diad, in which the transverse (T) tubule of the invaginated cell membra...

journal_title：FEBS letters

authors： Komazaki S,Nishi M,Takeshima H

更新日期：2003-05-08 00:00:00

abstract：:Erythroid spectrin is the main component of the red cell membrane skeleton, which is very important in determining the shape, resistance to mechanical stresses and deformability of red cells. Previously we demonstrated that human erythroid alpha-spectrin is ubiquitinated in vitro and in vivo, and using recombinant pep...

journal_title：FEBS letters

authors： Galluzzi L,Paiardini M,Lecomte MC,Magnani M

更新日期：2001-02-02 00:00:00

abstract：:The effects of ribosomal protein L5 on the conformation of 5 S rRNA in the 5 S rRNA-protein L5 complex extracted from rat liver ribosomes have been studied by laser Raman spectroscopy. A comparison of the spectra shows small protein-induced conformational changes in the 5 S rRNA, but most of the base-paired regions ap...

journal_title：FEBS letters

authors： Fabian H,Böhm S,Carius W,Misselwitz R,Welfle H

更新日期：1983-05-08 00:00:00

abstract：:Subcellular fractionation revealed that a significant fraction of total sphingosine kinase, the enzyme that phosphorylates sphingosine to form the bioactive lipid metabolite sphingosine-1-phosphate, resides in the nuclei of Swiss 3T3 cells, localized to both the nuclear envelope and the nucleoplasm. Platelet-derived g...

journal_title：FEBS letters

authors： Kleuser B,Maceyka M,Milstien S,Spiegel S

更新日期：2001-08-10 00:00:00

abstract：:Nitric oxide (.NO) synthase (NOS) activity in subcellular fractions from cultured endothelial cells (EC) and lipopolysaccharide-activated J774.2 monocyte/macrophages was investigated by monitoring the .NO-mediated increase in intracellular cyclic GMP in LLC-PK1 pig kidney epithelial cells. The constitutive NOS in EC (...

journal_title：FEBS letters

authors： Hecker M,Walsh DT,Vane JR

更新日期：1991-12-09 00:00:00

abstract：:Osteogenesis depends on a coordinated network of transcription factors including Sp7. Emerging evidence indicates that microRNAs (miRNAs) act as pivotal regulators in various biological processes including osteoblast proliferation and differentiation. Here, we investigated the effect of miR-145 on osteogenic different...

journal_title：FEBS letters

authors： Jia J,Tian Q,Ling S,Liu Y,Yang S,Shao Z

更新日期：2013-09-17 00:00:00

abstract：:The mucosal epithelium secretes a variety of antimicrobial peptides that act as part of the innate immune system to protect against invading microbes. Here, we describe the functional properties of human defensin (HD) 5, the major antimicrobial peptide produced by Paneth cells in the ileum, in relation to its structur...

journal_title：FEBS letters

authors： de Leeuw E,Burks SR,Li X,Kao JP,Lu W

更新日期：2007-02-06 00:00:00