Abstract:
:alpha-1-Antitrypsin is found in hepatocytes as a high-mannose glycoprotein (Mr 49 000), extracellularly as a complex-type glycoprotein (Mr 54 000). Deglycosylation of both forms with peptide: N-glycosidase led to proteins of identical app. Mr (41 000). The sequence of 26 N-terminal amino acids of rat alpha 1-antitrypsin was determined. A high content of polar amino acids was found. The partially characterized presequence of in vitro synthesized alpha 1-antitrypsin showed a cluster of hydrophobic amino acids. A pre-peptide of 24 amino acids is proposed. There is no evidence for the existence of a propeptide.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Gross V,Kaiser C,Tran-Thi TA,Schmelzer E,Witt I,Plummer TH Jr,Heinrich PCdoi
10.1016/0014-5793(83)80069-6subject
Has Abstractpub_date
1983-01-24 00:00:00pages
201-5issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(83)80069-6journal_volume
151pub_type
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