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Metastasis tumor antigen 1 is involved in the resistance to heat stress-induced testicular apoptosis.

Abstract：

:Our previous study documented the expression of Mta1 during spermatogenesis. Here, we present evidence for a possible involvement of Mta1 in the regulation of testicular function, possibly by interacting with p53. A notable decrease of Mta1 expression was revealed at postsurgical day 6, consistent with the previously reported upregulation of p53 in mouse cryptorchidism. Furthermore, in vitro over-expression of Mta1 could remarkably elevate the resistance capability of spermatogenic tumor cells against heat-induced apoptosis with a marked impairment of p53 expression. These findings indicate that Mta1 may operate as a negative modifier of apoptosis by interacting with p53 during gametogenesis.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Li W,Bao W,Ma J,Liu X,Xu R,Wang RA,Zhang Y

doi

10.1016/j.febslet.2008.02.013

subject

Has Abstract

pub_date

2008-03-19 00:00:00

pages

869-73

issue

6

eissn

0014-5793

issn

1873-3468

pii

S0014-5793(08)00118-X

journal_volume

582

pub_type

杂志文章

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