Abstract:
:Thioredoxins are a class of small proteins that play a key role in regulating many cellular redox processes. We report here the characterization of the first member of the thioredoxin family in metazoans that is mainly associated with neurons. The Caenorhabditis elegans gene B0228.5 encodes a thioredoxin (TRX-1) that is expressed in ASJ ciliated sensory neurons, and to some extent also in the posterior-most intestinal cells. TRX-1 is active at reducing protein disulfides in the presence of a heterologous thioredoxin reductase. A mutant worm strain carrying a null allele of the trx-1 gene displays a reproducible decrease in both mean and maximum lifespan when compared to wild-type. The identification and characterization of TRX-1 paves the way to use C. elegans as an in vivo model to study the role of thioredoxins in lifespan and nervous system physiology and pathology.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Miranda-Vizuete A,Fierro González JC,Gahmon G,Burghoorn J,Navas P,Swoboda Pdoi
10.1016/j.febslet.2005.12.046keywords:
subject
Has Abstractpub_date
2006-01-23 00:00:00pages
484-90issue
2eissn
0014-5793issn
1873-3468pii
S0014-5793(05)01529-2journal_volume
580pub_type
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