Abstract:
:Activation of p53 plays a central role in the cell's response to various stress signals. We investigated whether p53 is activated upon disruption of actin microfilaments, caused by cytochalasin D (CD). We show that treatment with CD leads to accumulation of p53 in the cells and activation of p53-dependent transcription. Treatment with CD led to arrest of G1-to-S transition in cells retaining wild-type p53, while cells with inactivated p53 showed partial rescue from it. CD also induces apoptosis in p53+/+, but not in p53-/- cells. The obtained data suggest that disruption of the actin microfilaments activates p53-dependent pathways.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Rubtsova SN,Kondratov RV,Kopnin PB,Chumakov PM,Kopnin BP,Vasiliev JMdoi
10.1016/s0014-5793(98)00692-9subject
Has Abstractpub_date
1998-07-03 00:00:00pages
353-7issue
3eissn
0014-5793issn
1873-3468pii
S0014-5793(98)00692-9journal_volume
430pub_type
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