Differential role of PPAR gamma in the regulation of UCP-1 and adipogenesis by TNF-alpha in brown adipocytes.


:Extracellular regulated kinases (ERKs) mediate the inhibitory effect of tumor necrosis factor alpha (TNF-alpha) on uncoupling protein-1 (UCP-1), but not on lipid accumulation. TNF-alpha-induced ERK-dependent peroxisome proliferator activator receptor gamma (PPAR gamma) phosphorylation could be responsible for UCP-1 downregulation. Thus, the negative effect of TNF-alpha on UCP-1 mRNA expression at 4-5 h, under basal conditions or in cells treated with the PPAR gamma agonist, rosiglitazone, was reversed by the MEK1 inhibitor PD98059. In contrast, fatty acid synthase and malic enzyme mRNA downregulation was not prevented. Moreover, rosiglitazone has no positive effect on adipogenic gene expression or lipid accumulation. Therefore, there is a differential regulation of thermogenic and adipogenic differentiation by PPAR gamma, which might account for the differences in the TNF-alpha regulation through ERKs.




FEBS letters


Porras A,Valladares A,Alvarez AM,Roncero C,Benito M





Has Abstract


2002-06-05 00:00:00














  • mRNA 5' ends targeted by cytoplasmic recapping cluster at CAGE tags and select transcripts are alternatively spliced.

    abstract::Until cytoplasmic recapping was discovered, decapping was thought to irreversibly destine an mRNA to degradation. Contradicting this idea, we readily observe mRNAs targeted by cytoplasmic capping in uncapped, yet stable forms. 5' rapid amplification of cDNA ends (RACE) shows that nearly all uncapped ends correspond to...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Berger MR,Alvarado R,Kiss DL

    更新日期:2019-04-01 00:00:00

  • Binding of IL-4 to the IL-13Ralpha(1)/IL-4Ralpha receptor complex leads to STAT3 phosphorylation but not to its nuclear translocation.

    abstract::Interleukin-4 (IL-4) is a pleiotropic cytokine, which acts on both hematopoietic and non-hematopoietic cells, through different types of receptor complexes. In this study, we report that in human B cells, IL-4 caused rapid phosphorylation of Janus kinase (JAK) 1 and JAK3 tyrosine kinases. In keratinocytes, the hematop...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Wery-Zennaro S,Letourneur M,David M,Bertoglio J,Pierre J

    更新日期:1999-12-24 00:00:00

  • Calcium and mitochondria.

    abstract::The literature suggests that the physiological functions for which mitochondria sequester Ca(2+) are (1). to stimulate and control the rate of oxidative phosphorylation, (2). to induce the mitochondrial permeability transition (MPT) and perhaps apoptotic cell death, and (3). to modify the shape of cytosolic Ca(2+) pul...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Gunter TE,Yule DI,Gunter KK,Eliseev RA,Salter JD

    更新日期:2004-06-01 00:00:00

  • An improved purification of lactose permease.

    abstract::The integral membrane protein lactose permease of Escherichia coli was purified to homogeneity in detergent micelles. No other proteins could be detected in the final product. The molar ratio of lactose permease to lipid was less than 0.2 in detergent solution, thus the preparation was essentially lipid-free. All mole...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Dornmair K

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  • Differences in catalytic activity between rat testicular and ovarian carbonyl reductases are due to two amino acids.

    abstract::The sequences of rat testis carbonyl reductase (rCR1) and rat ovary carbonyl reductase (rCR2) are 98% identical, differing only at amino acids 140, 141, 143, 235 and 238. Despite such strong sequence identity, we find that rCR1 and rCR2 have different catalytic constants for metabolism of menadione and 4-benzoyl-pyrid...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Sciotti MA,Tam S,Wermuth B,Baker ME

    更新日期:2006-01-09 00:00:00

  • Interaction of viper venom serine peptidases with thrombin receptors on human platelets.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Santos BF,Serrano SM,Kuliopulos A,Niewiarowski S

    更新日期:2000-07-21 00:00:00

  • Effects of detyrosinated tubulin on Na+,K+-ATPase activity and erythrocyte function in hypertensive subjects.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Amaiden MR,Santander VS,Monesterolo NE,Nigra AD,Rivelli JF,Campetelli AN,Pie J,Casale CH

    更新日期:2015-01-30 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Blanchard L,Blackledge MJ,Marion D,Guerlesquin F

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  • Dimerization, ubiquitylation and endocytosis go together in growth hormone receptor function.

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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Strous GJ,Gent J

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Juillerat MA,Barkas T,Tzartos SJ

    更新日期:1984-03-12 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Nilsson T,Slusarewicz P,Hoe MH,Warren G

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Rehm A,Ploegh HL

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kamble PR,Rane S,Breed AA,Joseph S,Mahale SD,Pathak BR

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Colloc'h N,Prangé T

    更新日期:2014-05-02 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Matsuo Y,Tsujita M,Mizoguchi K,Ichikawa Y

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Dumas J,Hurion N,Weill R,Keil B

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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Simon J,Einsle O,Kroneck PM,Zumft WG

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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Iwamoto T,Hiroaki H,Furuichi Y,Wada K,Satoh M,Satoh M,Osada T,Gagnon C

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: van Heyningen S

    更新日期:1983-11-28 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Giles NM,Gutowski NJ,Giles GI,Jacob C

    更新日期:2003-01-30 00:00:00