Abstract:
:The yeast PMR2/ENA1 gene encodes an ATPase involved in sodium extrusion and induced by NaCl. At low salt concentrations (0.3 M) induction is mediated by the HOG-MAP kinase pathway, a system activated by non-specific osmotic stress. At high salt concentrations (0.8 M) induction is mediated by the protein phosphatase calcineurin and is specific for sodium. Protein kinase A and Sis2p/Hal3p modulate PMR2/ENA1 expression as negative and positive factors, respectively but Sis2p/Hal3p does not participate in the transduction of the salt signal. Salt stress decreases the level of cAMP and the resulting decrease in protein kinase A activity may contribute to HOG-mediated induction.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Márquez JA,Serrano Rdoi
10.1016/0014-5793(96)00157-3subject
Has Abstractpub_date
1996-03-11 00:00:00pages
89-92issue
1-2eissn
0014-5793issn
1873-3468journal_volume
382pub_type
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