Multiple transduction pathways regulate the sodium-extrusion gene PMR2/ENA1 during salt stress in yeast.


:The yeast PMR2/ENA1 gene encodes an ATPase involved in sodium extrusion and induced by NaCl. At low salt concentrations (0.3 M) induction is mediated by the HOG-MAP kinase pathway, a system activated by non-specific osmotic stress. At high salt concentrations (0.8 M) induction is mediated by the protein phosphatase calcineurin and is specific for sodium. Protein kinase A and Sis2p/Hal3p modulate PMR2/ENA1 expression as negative and positive factors, respectively but Sis2p/Hal3p does not participate in the transduction of the salt signal. Salt stress decreases the level of cAMP and the resulting decrease in protein kinase A activity may contribute to HOG-mediated induction.




FEBS letters


Márquez JA,Serrano R




Has Abstract


1996-03-11 00:00:00












  • Apamin-sensitive potassium channels mediate agonist-induced oscillations of membrane potential in pituitary gonadotrophs.

    abstract::In cultured rat pituitary gonadotrophs, gonadotropin-releasing hormone (GnRH) induces rapid hyperpolarization of the cell membrane and causes cessation of the spontaneous electrical activity present in non-stimulated cells. This initial response to GnRH is followed by slow oscillations of membrane potential (Vm) which...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kukuljan M,Stojilković SS,Rojas E,Catt KJ

    更新日期:1992-04-13 00:00:00

  • Crystal structure and molecular mechanism of an aspartate/glutamate racemase from Escherichia coli O157.

    abstract::EcL-DER, the aspartate/glutamate racemase from the pathogen Escherichia coli O157, exhibits racemase activity for l-aspartate and l-glutamate. This study reports the crystal structures of apo-EcL-DER, the EcL-DER-l-aspartate and the EcL-DER-d-aspartate complexes. The EcL-DER structure contains two domains, forming pse...

    journal_title:FEBS letters

    pub_type: 信件


    authors: Liu X,Gao F,Ma Y,Liu S,Cui Y,Yuan Z,Kang X

    更新日期:2016-04-01 00:00:00

  • Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Wu DM,Zhang P,Liu RY,Sang YX,Zhou C,Xu GC,Yang JL,Tong AP,Wang CT

    更新日期:2014-05-21 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Vener AV,Loeb J

    更新日期:1992-06-01 00:00:00

  • Collagenase in mineralized tissues of human teeth.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Dumas J,Hurion N,Weill R,Keil B

    更新日期:1985-07-22 00:00:00

  • Yeast as a model system for studying lipid homeostasis and function.

    abstract::Lipids are essential eukaryotic cellular constituents. Lipid metabolism has a strong impact on cell physiology, and despite good progress in this area, many important basic questions remain unanswered concerning the functional diversity of lipid species and on the mechanisms that cells employ to sense and adjust their...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Santos AX,Riezman H

    更新日期:2012-08-31 00:00:00

  • Substitution of a conserved aspartate allows cation-induced polymerization of FtsZ.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Scheffers DJ,de Wit JG,den Blaauwen T,Driessen AJ

    更新日期:2001-04-06 00:00:00

  • Activation of recombinant human SK4 channels by metal cations.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Cao YJ,Houamed KM

    更新日期:1999-03-05 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Lee HJ,Su Y,Lui WY,Chau GY,Yin PH,Lee HC,Chi CW

    更新日期:2008-03-05 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Wallach T,Kramer A

    更新日期:2015-06-22 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Preissner R,Egner U,Saenger W

    更新日期:1991-08-19 00:00:00

  • A new approach for EPR detection of hydroxyl radicals by reaction with sterically hindered cyclic amines and oxygen.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Rosenthal I,Krishna CM,Yang GC,Kondo T,Riesz P

    更新日期:1987-09-28 00:00:00

  • Parallel purine-pyrimidine-purine triplex: experimental evidence for existence.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Shchyolkina AK,Borisova OF,Minyat EE,Timofeev EN,Il'icheva IA,Khomyakova EB,Florentiev VL

    更新日期:1995-06-19 00:00:00

  • cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3).

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kiuchi Y,Suzuki H,Hirohashi T,Tyson CA,Sugiyama Y

    更新日期:1998-08-14 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Herrmann JL,Delahay R,Gallagher A,Robertson B,Young D

    更新日期:2000-05-19 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Ovchinnikov YuA,Arystarkhova EA,Arzamazova NM,Dzhandzhugazyan KN,Efremov RG,Nabiev IR,Modyanov NN

    更新日期:1988-01-25 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: O'Connor JE,Costell M,Grisolía S

    更新日期:1984-01-30 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Feniouk BA,Junge W

    更新日期:2005-09-26 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Yamaguchi N,Kukita T,Li YJ,Kamio N,Fukumoto S,Nonaka K,Ninomiya Y,Hanazawa S,Yamashita Y

    更新日期:2008-02-06 00:00:00

  • Inhibition of epidermal growth factor-dependent protein tyrosine phosphorylation by phorbol myristate acetate is mediated by protein tyrosine phosphatase activity.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Errasfa M,Stern A

    更新日期:1994-02-14 00:00:00

  • The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios.

    abstract::The accumulation of amyloid-beta (Aβ) and tau aggregates is a pathological hallmark of Alzheimer's disease. Both polypeptides form fibrillar deposits, but several lines of evidence indicate that Aβ and tau form toxic oligomeric aggregation intermediates. Depleting such structures could thus be a powerful therapeutic s...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Wobst HJ,Sharma A,Diamond MI,Wanker EE,Bieschke J

    更新日期:2015-01-02 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Young P,Cawthorne MA,Levy AL,Wilson K

    更新日期:1984-10-15 00:00:00

  • Regulation of osteopontin expression in rat mesangial cells.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Pröls F,Heidgress D,Rupprecht HD,Marx M

    更新日期:1998-01-23 00:00:00

  • Molecular mechanism of molt-inhibiting hormone (MIH) induced suppression of ecdysteroidogenesis in the Y-organ of mud crab: Scylla serrata.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Imayavaramban L,Dhayaparan D,Devaraj H

    更新日期:2007-11-13 00:00:00

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Itsuki Y,Saeki M,Nakahara H,Egusa H,Irie Y,Terao Y,Kawabata S,Yatani H,Kamisaki Y

    更新日期:2008-07-09 00:00:00

  • Modulation of functional activities of the neurotoxin from black widow spider venom.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Grishin EV,Himmelreich NH,Pluzhnikov KA,Pozdnyakova NG,Storchak LG,Volkova TM,Woll PG

    更新日期:1993-12-27 00:00:00

  • Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor.

    abstract::Subcellular fractionation revealed that a significant fraction of total sphingosine kinase, the enzyme that phosphorylates sphingosine to form the bioactive lipid metabolite sphingosine-1-phosphate, resides in the nuclei of Swiss 3T3 cells, localized to both the nuclear envelope and the nucleoplasm. Platelet-derived g...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Kleuser B,Maceyka M,Milstien S,Spiegel S

    更新日期:2001-08-10 00:00:00

  • Receptors for mammalian steroid hormones in microbes and plants.

    abstract::Steroids are of universal occurrence, present variously as cell wall constituents and bioregulators. A number of bacteria, fungi, and photosynthetic vascular plants synthesize steroids that are hormonally active in the animal world. The cellular effect of such steroids in microbes and plants appears by and large to be...

    journal_title:FEBS letters

    pub_type: 杂志文章,评审


    authors: Agarwal MK

    更新日期:1993-05-17 00:00:00

  • Expression of biologically active hormone-sensitive lipase in mammalian (COS) cells.

    abstract::cDNAs encoding rat adipose tissue hormone-sensitive lipase were expressed in COS cells, under the control of the SV40 promoter to half the level in rat adipocytes, the richest native source of the enzyme. A cDNA lacking most of the long 5'-untranslated region of the full-length rat hormone-sensitive lipase cDNA was, w...

    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: Holm C,Davis RC,Fredrikson G,Belfrage P,Schotz MC

    更新日期:1991-07-08 00:00:00

  • Genomic exploration of the hemiascomycetous yeasts: 15. Pichia sorbitophila.

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    journal_title:FEBS letters

    pub_type: 杂志文章


    authors: de Montigny J,Spehner C,Souciet J,Tekaia F,Dujon B,Wincker P,Artiguenave F,Potier S

    更新日期:2000-12-22 00:00:00