Abstract:
:Stable liposomes were rendered pH-sensitive by complexation to a polymer that undergoes marked temperature- and pH-dependent water solubility changes. The N-isopropylacrylamide-methacrylic acid copolymer was prepared with or without octadecyl acrylate. At pH below the phase transition of the polymer, egg phosphatidylcholine liposomes quickly released a part of their contents only when associated with the octadecyl aliphatic chain grafted polymer at 37 degrees C. Similarly, sterically stabilized liposomes also quickly released a significant part of the entrapped fluorescent markers at pH 5.5-4.9, values corresponding to those of endosomes/lysosomes. This new pH-sensitive liposome-polymer system may further improve the efficiency of liposomal drug delivery.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Meyer O,Papahadjopoulos D,Leroux JCdoi
10.1016/s0014-5793(97)01520-2subject
Has Abstractpub_date
1998-01-02 00:00:00pages
61-4issue
1eissn
0014-5793issn
1873-3468pii
S0014-5793(97)01520-2journal_volume
421pub_type
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