Abstract:
:CREB binding protein (CBP) is an acetyltransferase that plays an important role in many biological processes. Here, we show that Akt phosphorylates CBP at threonine 1871 and suppresses its acetyltransferase activity by impeding the binding of CBP to histone H3, which results in a decrease in lysine K18 acetylation and dysregulation of target genes. Our results demonstrate that Akt regulates acetyltransferase activity through CBP phosphorylation, which may contribute to tumorigenesis.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Liu Y,Xing ZB,Zhang JH,Fang Ydoi
10.1016/j.febslet.2013.02.023subject
Has Abstractpub_date
2013-04-02 00:00:00pages
847-53issue
7eissn
0014-5793issn
1873-3468pii
S0014-5793(13)00154-3journal_volume
587pub_type
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