Adrenal chromaffin granules and secretory granules from thyroid parafollicular cells have several common antigens.

Abstract:

:The presence of various antigens in two types of isolated endocrine vesicles (chromaffin granules and secretory vesicles of thyroid parafollicular cells) was investigated by immunoblotting. The two types of vesicles have three common secretory proteins: chromogranin A, chromogranin B and secretogranin II. Furthermore, six common membrane antigens were found: cytochrome b-561, carboxypeptidase H, glycoprotein II, glycoprotein III, synaptin/synaptophysin and SV 2. These results demonstrate that vesicles obtained from neural crest-derived endocrine cells not only share several common secretory peptides and proteins, but also have common properties as far as their membrane antigens are concerned.

journal_name

FEBS Lett

journal_title

FEBS letters

authors

Weiler R,Cidon S,Gershon MD,Tamir H,Hogue-Angeletti R,Winkler H

doi

10.1016/0014-5793(89)81595-9

subject

Has Abstract

pub_date

1989-11-06 00:00:00

pages

457-9

issue

2

eissn

0014-5793

issn

1873-3468

pii

0014-5793(89)81595-9

journal_volume

257

pub_type

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