Abstract:
:Treatment of human neutrophils with triphenyltin chloride (TPTCl)-inhibited superoxide (O-2) production stimulated with phorbol myristate acetate (PMA). TPTCl was more potent as inhibitor of O-2 production than other phenyltin compounds. The O-2 production by the xanthine oxidase-acetaldehyde system was not inhibited by TPTCl. This finding indicates that TPTCl does not itself react with O-2. Furthermore, TPTCl did not influence the isolated NADPH oxidase at all, though O-2 production of neutrophils stimulated with PMA in the presence of TPTCl was inhibited. These results indicate that TPTCl inhibits the activation process of the O-2 generating system.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Matsui H,Wada O,Ushijima Y,Akuzawa Tdoi
10.1016/0014-5793(83)80296-8subject
Has Abstractpub_date
1983-12-12 00:00:00pages
251-4issue
2eissn
0014-5793issn
1873-3468pii
0014-5793(83)80296-8journal_volume
164pub_type
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